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Functional maps of direct electrical stimulation-induced speech arrest and anomia: a multicentre retrospective study.
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In: Brain : a journal of neurology, vol 144, iss 8 (2021)
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Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
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In: Brain : a journal of neurology, vol 143, iss 10 (2020)
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C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.
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In: Neurology, vol 95, iss 24 (2020)
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Language disparity is not a significant barrier for time-sensitive care of acute ischemic stroke.
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In: BMC neurology, vol 20, iss 1 (2020)
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Factors that predict diagnostic stability in neurodegenerative dementia.
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In: Journal of neurology, vol 266, iss 8 (2019)
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Factors that predict diagnostic stability in neurodegenerative dementia.
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In: Journal of neurology, vol 266, iss 8 (2019)
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Abstract:
ObjectiveTo determine the frequency and characteristics of clinical diagnostic change in frontotemporal dementia (FTD)-spectrum syndromes and Alzheimer's disease (AD)-type dementia.MethodsWe reviewed records and categorized diagnostic changes in patients seen ≥ 2 times with behavioral variant FTD (bvFTD, n = 99), nonfluent and semantic variant primary progressive aphasia (nfvPPA, n = 32; svPPA, n = 59), corticobasal syndrome (CBS, n = 40), progressive supranuclear palsy-Richardson syndrome (PSP-RS, n = 34), and AD-type dementia (n = 49). For bvFTD, we compared patients with and without diagnostic change, and assessed predictors of diagnostic change by logistic regression.ResultsInitial diagnoses changed infrequently at subsequent visits in svPPA (6.8%), PSP-RS (8.8%), and nfvPPA (12.5%), with rare changes largely involving clinicopathological overlap or diagnostic ambiguity. Changes in AD-type dementia (30.6%) and CBS (37.5%) were more common, but reflected greater specificity, predicted co-pathology, or overlapping syndromes. Diagnostic change in bvFTD was also common (32.3%), but more diverse, including motor neuron disease development, alternative neurodegenerative syndromes, and non-neurodegenerative diseases. Diagnostic change occurred more often in those who met possible rather than probable bvFTD criteria (70.6% vs 15.3%, p < 0.001). Patients with stable diagnoses showed greater overall impairment, bvFTD behavioral severity, and atrophy in core right-hemisphere bvFTD regions. Patients with diagnostic change had more severe depression (p < 0.05) and more frequent contributing, secondary diagnoses (p = 0.01), such as cerebrovascular disease. By logistic regression, the accuracy of predicting stable bvFTD diagnoses using first-visit data was 80%.ConclusionbvFTD displays more diverse diagnostic change than other neurodegenerative syndromes. First-visit bvFTD diagnoses may waver if based on meeting possible criteria only.
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Keyword:
Aged; Alzheimer Disease; Alzheimer's disease; Alzheimer’s disease; Aphasia; Clinical Sciences; Corticobasal degeneration; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurodegenerative Diseases; Neurology & Neurosurgery; Neurosciences; Predictive Value of Tests; Primary Progressive; Progressive; Progressive supranuclear palsy; Retrospective Studies; Supranuclear Palsy
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URL: https://escholarship.org/uc/item/4rz1t2j1
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Anomalous morphology in left hemisphere motor and premotor cortex of children who stutter
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New Directions in Treatments Targeting Stroke Recovery.
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In: Stroke, vol 49, iss 12 (2018)
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Human Sensorimotor Cortex Control of Directly Measured Vocal Tract Movements during Vowel Production.
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In: The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 38, iss 12 (2018)
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Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.
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In: Nature neuroscience, vol 21, iss 12 (2018)
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Peak alpha frequency is a neural marker of cognitive function across the autism spectrum.
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In: The European journal of neuroscience, vol 47, iss 6 (2018)
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Observing conversational laughter in frontotemporal dementia.
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In: Journal of neurology, neurosurgery, and psychiatry, vol 88, iss 5 (2017)
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Therapy and clinical trials in frontotemporal dementia: past, present, and future.
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In: Journal of neurochemistry, vol 138 Suppl 1, iss S1 (2016)
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Increased subcortical neural activity among HIV+ individuals during a lexical retrieval task.
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In: Neurobiology of disease, vol 92, iss Pt B (2016)
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Neuroeconomic dissociation of semantic dementia and behavioural variant frontotemporal dementia.
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In: Brain : a journal of neurology, vol 139, iss Pt 2 (2016)
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Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants
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In: Neurobiology of Aging, vol 36, iss 10 (2015)
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Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants
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In: Neurobiology of Aging, vol 36, iss 10 (2015)
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The effects of study task on prestimulus subsequent memory effects in the hippocampus.
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In: Hippocampus, vol 25, iss 11 (2015)
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