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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 8 of 8 1 Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood. ... Newbury, Dianne F; Gibson, Jenny; Conti-Ramsden, Gina. - : Apollo - University of Cambridge Repository, 2019 BASE Show details 2 Using polygenic profiles to predict variation in language and psychosocial outcomes in early and middle childhood Newbury, Dianne F.; Toseeb, Umar; Gibson, Jenny L.. - 2019 BASE Show details 3 Using polygenic profiles to predict variation in language and psychosocial outcomes in early and middle childhood Gibson, Jenny; Durkin, Kevin; Pickles, Andrew. - 2019 BASE Show details 4 Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood. Newbury, Dianne F; Gibson, Jenny; Conti-Ramsden, Gina; Pickles, Andrew; Durkin, Kevin; Toseeb, Umar. - : American Speech Language Hearing Association, 2019. : J Speech Lang Hear Res, 2019 Abstract: Purpose Children with poor language tend to have worse psychosocial outcomes compared to their typically developing peers. The most common explanations for such adversities focus on developmental psychological processes whereby poor language triggers psychosocial difficulties. Here, we investigate the possibility of shared biological effects by considering whether the same genetic variants, which are thought to influence language development, are also predictors of elevated psychosocial difficulties during childhood. Method Using data from the U.K.-based Avon Longitudinal Study of Parents and Children, we created a number of multi-single-nucleotide polymorphism polygenic profile scores, based on language and reading candidate genes (ATP2C2, CMIP, CNTNAP2, DCDC2, FOXP2, and KIAA0319, 1,229 single-nucleotide polymorphisms) in a sample of 5,435 children. Results A polygenic profile score for expressive language (8 years) that was created in a discovery sample (n = 2,718) predicted not only expressive language (8 years) but also peer problems (11 years) in a replication sample (n = 2,717). Conclusions These findings provide a proof of concept for the use of such a polygenic approach in child language research when larger data sets become available. Our indicative findings suggest consideration should be given to concurrent intervention targeting both linguistic and psychosocial development as early language interventions may not stave off later psychosocial difficulties in children. Keyword: Age Factors; Child; Child Language; Cohort Studies; Female; Humans; Infant; Language; Male; Multifactorial Inheritance; Preschool; Psychology URL: https://doi.org/10.17863/CAM.39549 https://www.repository.cam.ac.uk/handle/1810/292399 BASE Hide details 5 Standardizing test scores for a target population: The LMS method illustrated using language measures from the SCALES project Vamvakas, George; Norbury, Courtenay Frazier; Vitoratou, Silia. - : Public Library of Science, 2019 BASE Show details 6 Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood Newbury, Dianne F.; Gibson, Jenny L.; Conti-Ramsden, Gina. - : American Speech-Language-Hearing Association, 2019 BASE Show details 7 Standardizing test scores for a target population: The LMS method illustrated using language measures from the SCALES project Vitoratou, Silia; Gooch, Debbie; Pickles, Andrew. - : Public Library of Science, 2019 BASE Show details 8 Using polygenic profiles to predict variation in language and psychosocial outcomes in early and middle childhood Conti-Ramsden, Gina; Pickles, Andrew; Gibson, Jenny L.. - 2019 BASE Show details

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