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Maladaptive compensation of right fusiform gyrus in developmental dyslexia: A hub-based white matter network analysis
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In: ISSN: 0010-9452 ; Cortex ; https://hal.archives-ouvertes.fr/hal-03485452 ; Cortex, Elsevier, 2021, 145, pp.57-66. ⟨10.1016/j.cortex.2021.07.016⟩ (2021)
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Epidémiologie des troubles de la lecture en France : une comparaison du DSM-5 et de la CIM-11
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In: ISSN: 0999-792X ; EISSN: 0999-792X ; ANAE - Approche Neuropsychologique des Apprentissages Chez L'enfant ; https://hal.archives-ouvertes.fr/hal-03426038 ; ANAE - Approche Neuropsychologique des Apprentissages Chez L'enfant, ANAE/PLEIOMEDIA, A paraître (2021)
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Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France
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In: ISSN: 2045-2322 ; EISSN: 2045-2322 ; Scientific Reports ; https://hal.archives-ouvertes.fr/hal-02976092 ; Scientific Reports, Nature Publishing Group, 2020, 10, pp.17362. ⟨10.1038/s41598-020-74409-x⟩ (2020)
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Neuroanatomy of dyslexia: An allometric approach
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In: ISSN: 0953-816X ; EISSN: 1460-9568 ; European Journal of Neuroscience ; https://hal.archives-ouvertes.fr/hal-02976086 ; European Journal of Neuroscience, Wiley, 2020, 52 (6), pp.3595-3609. ⟨10.1111/ejn.14690⟩ (2020)
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Genome-wide association study reveals new insights into the heritability and genetic correlates of developmental dyslexia
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Gialluisi, Alessandro; Andlauer, Till,; Mirza-Schreiber, Nazanin; Moll, Kristina; Becker, Jessica; Hoffmann, Per; Ludwig, Kerstin,; Czamara, Darina; Pourcain, Beate St; Honbolygó, Ferenc; Tóth, Dénes; Csépe, Valéria; Huguet, Guillaume; Chaix, Yves; Iannuzzi, Stephanie; Demonet, Jean-Francois; Morris, Andrew,; Hulslander, Jacqueline; Willcutt, Erik,; DeFries, John,; Olson, Richard,; Smith, Shelley,; Pennington, Bruce,; Vaessen, Anniek; Maurer, Urs; Lyytinen, Heikki; Peyrard-Janvid, Myriam; Leppänen, Paavo,; Brandeis, Daniel; Bonte, Milene; Stein, John,; Talcott, Joel,; Fauchereau, Fabien; Wilcke, Arndt; Kirsten, Holger; Müller, Bent; Francks, Clyde; Bourgeron, Thomas; Monaco, Anthony,; Ramus, Franck; Landerl, Karin; Kere, Juha; Scerri, Thomas,; Paracchini, Silvia; Fisher, Simon,; Schumacher, Johannes; Nöthen, Markus,; Müller-Myhsok, Bertram; Schulte-Körne, Gerd
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In: ISSN: 1359-4184 ; EISSN: 1476-5578 ; Molecular Psychiatry ; https://hal.archives-ouvertes.fr/hal-02976104 ; Molecular Psychiatry, Nature Publishing Group, 2020, ⟨10.1038/s41380-020-00898-x⟩ (2020)
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Abstract:
International audience ; Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40–60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing associations at the single variant, gene, and pathway level, and estimating heritability using single-nucleotide polymorphism (SNP) data. We also calculated polygenic scores (PGSs) based on large-scale GWAS data for different neuropsychiatric disorders and cortical brain measures, educational attainment, and fluid intelligence, testing them for association with dyslexia status in our sample. We observed statistically significant (p < 2.8 × 10−6) enrichment of associations at the gene level, for LOC388780 (20p13; uncharacterized gene), and for VEPH1 (3q25), a gene implicated in brain development. We estimated an SNP-based heritability of 20–25% for DD, and observed significant associations of dyslexia risk with PGSs for attention deficit hyperactivity disorder (at pT = 0.05 in the training GWAS: OR = 1.23[1.16; 1.30] per standard deviation increase; p = 8 × 10−13), bipolar disorder (1.53[1.44; 1.63]; p = 1 × 10−43), schizophrenia (1.36[1.28; 1.45]; p = 4 × 10−22), psychiatric cross-disorder susceptibility (1.23[1.16; 1.30]; p = 3 × 10−12), cortical thickness of the transverse temporal gyrus (0.90[0.86; 0.96]; p = 5 × 10−4), educational attainment (0.86[0.82; 0.91]; p = 2 × 10−7), and intelligence (0.72[0.68; 0.76]; p = 9 × 10−29). This study suggests an important contribution of common genetic variants to dyslexia risk, and novel genomic overlaps with psychiatric conditions like bipolar disorder, schizophrenia, and cross-disorder susceptibility. Moreover, it revealed the presence of shared genetic foundations with a neural correlate previously implicated in dyslexia by neuroimaging evidence.
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Keyword:
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
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URL: https://hal.archives-ouvertes.fr/hal-02976104/file/MolPsy20.pdf https://hal.archives-ouvertes.fr/hal-02976104/document https://doi.org/10.1038/s41380-020-00898-x https://hal.archives-ouvertes.fr/hal-02976104
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The epidemiology of cognitive development
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In: https://hal.archives-ouvertes.fr/hal-02927365 ; 2020 (2020)
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Influences of the early family environment and long-term vocabulary development on the structure of white matter pathways: A longitudinal investigation
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In: ISSN: 1878-9293 ; EISSN: 1878-9307 ; Developmental Cognitive Neuroscience ; https://hal.archives-ouvertes.fr/hal-02971250 ; Developmental Cognitive Neuroscience, Elsevier, 2020, 42, pp.100767. ⟨10.1016/j.dcn.2020.100767⟩ (2020)
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Risk of early neurodevelopmental outcomes associated with prenatal exposure to the antiepileptic drugs most commonly used during pregnancy: a French nationwide population-based cohort study
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In: ISSN: 2044-6055 ; BMJ Open ; https://hal.archives-ouvertes.fr/hal-02976080 ; BMJ Open, BMJ Publishing Group, 2020, 10 (6), pp.e034829. ⟨10.1136/bmjopen-2019-034829⟩ (2020)
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Sex differences in academic achievement are modulated by evaluation type
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In: ISSN: 1041-6080 ; Learning and Individual Differences ; https://hal.archives-ouvertes.fr/hal-02976087 ; Learning and Individual Differences, Elsevier, 2020, 83-84, pp.101935. ⟨10.1016/j.lindif.2020.101935⟩ (2020)
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A Meta-Analytic Review of the Benefit of Spacing out Retrieval Practice Episodes on Retention
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In: ISSN: 1040-726X ; EISSN: 1573-336X ; Educational Psychology Review ; https://hal.archives-ouvertes.fr/hal-02976100 ; Educational Psychology Review, Springer Verlag, 2020, ⟨10.1007/s10648-020-09572-8⟩ (2020)
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A universal reading network and its modulation by writing system and reading ability in French and Chinese children
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In: ISSN: 2050-084X ; EISSN: 2050-084X ; eLife ; https://hal.archives-ouvertes.fr/hal-03003551 ; eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.54591⟩ (2020)
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Adjusting for allometric scaling in ABIDE I challenges subcortical volume differences in autism spectrum disorder
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In: ISSN: 1065-9471 ; EISSN: 1097-0193 ; Human Brain Mapping ; https://hal.archives-ouvertes.fr/hal-02976094 ; Human Brain Mapping, Wiley, 2020, ⟨10.1002/hbm.25145⟩ (2020)
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Correlates of linguistic rhythm in the speech signal - Dataset ...
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A universal reading network and its modulation by writing system and reading ability in French and Chinese children
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In: eLife (2020)
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White matter network connectivity deficits in developmental dyslexia
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In: ISSN: 1065-9471 ; EISSN: 1097-0193 ; Human Brain Mapping ; https://hal.archives-ouvertes.fr/hal-02158487 ; Human Brain Mapping, Wiley, 2019, 40 (2), pp.505-516. ⟨10.1002/hbm.24390⟩ (2019)
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Developmental trajectories of motor skills during the preschool period
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In: ISSN: 1018-8827 ; European Child and Adolescent Psychiatry ; https://hal.archives-ouvertes.fr/hal-02324795 ; European Child and Adolescent Psychiatry, Springer Verlag (Germany), 2019, 28 (11), pp.1461-1474. ⟨10.1007/s00787-019-01311-x⟩ (2019)
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The Effect of Older Siblings on Language Development as a Function of Age Difference and Sex
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In: ISSN: 0956-7976 ; Psychological Science ; https://hal.archives-ouvertes.fr/hal-02324780 ; Psychological Science, Association for Psychological Science, 2019, 30 (9), pp.1333-1343. ⟨10.1177/0956797619861436⟩ (2019)
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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In: ISSN: 2158-3188 ; EISSN: 2158-3188 ; Translational Psychiatry ; https://hal.archives-ouvertes.fr/hal-02158502 ; Translational Psychiatry, Nature Pub. Group, 2019, 9, pp.77. ⟨10.1038/s41398-019-0402-0⟩ (2019)
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Sex differences in psychomotor development during the preschool period: A longitudinal study of the effects of environmental factors and of emotional, behavioral, and social functioning
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In: ISSN: 0022-0965 ; EISSN: 1096-0457 ; Journal of Experimental Child Psychology ; https://hal.archives-ouvertes.fr/hal-02158494 ; Journal of Experimental Child Psychology, Elsevier, 2019, 178, pp.369-384. ⟨10.1016/j.jecp.2018.09.002⟩ (2019)
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Does pre-testing promote better retention than post-testing?
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In: ISSN: 2056-7936 ; EISSN: 2056-7936 ; npj Science of Learning ; https://hal.archives-ouvertes.fr/hal-02324042 ; npj Science of Learning, Nature Publishing Group, 2019, 4 (1), ⟨10.1038/s41539-019-0053-1⟩ (2019)
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