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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Hits 1 – 13 of 13 1 Cerebral lateralisation of first and second languages in bilinguals assessed using functional transcranial Doppler ultrasound Bishop, Dorothy V. M.; Grabitz, Clara R.; Harte, Sophie C.... In: Wellcome Open Res (2021) BASE Show details 2 Profile of language abilities in a sample of adults with developmental disorders Bradshaw, Abigail R.; Woodhead, Zoe V. J.; Thompson, Paul A.. - : John Wiley & Sons Ltd., 2021 BASE Show details 3 Profile of language abilities in a sample of adults with developmental disorders Bradshaw, Abigail R.; Woodhead, Zoe V. J.; Thompson, Paul A.... In: Dyslexia (2020) BASE Show details 4 Investigation into inconsistent lateralisation of language functions as a potential risk factor for language impairment Bradshaw, Abigail R.; Woodhead, Zoe V. J.; Thompson, Paul A.. - : Wiley-Blackwell Publishing Ltd., 2020 BASE Show details 5 How does iReadMore therapy change the reading network of patients with central alexia? Kerry, Sheila J; Aguilar, Oscar M; Penny, William; Crinion, Jennifer T; Leff, Alex P; Woodhead, Zoe V J. - 2019 Abstract: Central alexia (CA) is an acquired reading disorder co-occurring with a generalised language deficit (aphasia). The roles of perilesional and ipsilesional tissue in recovery from post-stroke aphasia are unclear. We investigated the impact of reading training (using iReadMore, a therapy app) on the connections within and between the right and left hemisphere of the reading network of patients with CA. In patients with pure alexia, iReadMore increased feedback from left inferior frontal region (IFG) to the left occipital (OCC) region. We aimed to identify if iReadMore therapy was effective through a similar mechanism in CA patients.Participants with chronic post-stroke CA (n=23) completed 35 hours of iReadMore training over four weeks. Reading accuracy for trained and untrained words was assessed before and after therapy. The neural response to reading trained and untrained words in the left and right OCC, ventral occipitotemporal (vOT) and IFG was examined using event-related magnetoencephalography.The training-related modulation in effective connectivity between regions was modelled at the group level with Dynamic Causal Modelling.iReadMore training improved participants' reading accuracy by an average of 8.4% (range: -2.77 to 31.66) while accuracy for untrained words was stable. Training increased regional sensitivity in bilateral frontal and occipital regions, and strengthened feedforward connections within the left hemisphere. Our data suggests that iReadMore training in these patients modulates lower-order visual representations, as opposed to higher-order, more abstract ones, in order to improve word reading accuracy.SIGNIFICANCE STATEMENTThis is the first study to conduct a network-level analyses of therapy effects in participants with post-stroke central alexia. When patients trained with iReadMore (a multimodal, behavioural, mass practice, computer-based therapy), reading accuracy improved by an average 8.4% on trained items. A network analysis of the magnetoencephalography data associated with this improvement revealed an increase in regional sensitivity in bilateral frontal and occipital regions and strengthening of feedforward connections within the left hemisphere. This indicates that in CA patients iReadMore engages lower-order, intact resources within the left hemisphere (posterior to their lesion locations) to improve word reading. This provides a foundation for future research to investigate reading network modulation in different CA subtypes, or for sentence level therapy. URL: https://ueaeprints.uea.ac.uk/id/eprint/71246/ https://ueaeprints.uea.ac.uk/id/eprint/71246/1/Accepted_Manuscript.pdf https://doi.org/10.1523/JNEUROSCI.1426-18.2019 BASE Hide details 6 Investigation into inconsistent lateralisation of language functions as a potential risk factor for language impairment Bradshaw, Abigail R.; Woodhead, Zoe V. J.; Thompson, Paul A.. - : John Wiley and Sons Inc., 2019 BASE Show details 7 Auditory training changes temporal lobe connectivity in Wernicke's aphasia: a randomised trial Woodhead, Zoe V. J.; Crinion, Jennifer; Teki, Sundeep. - 2017 BASE Show details 8 Measuring language lateralisation with different language tasks : a systematic review Bradshaw, Abigail R.; Thompson, Paul A.; Wilson, Alexander C.. - : PeerJ, 2017 BASE Show details 9 The right hemisphere supports but does not replace left hemisphere auditory function in patients with persisting aphasia Teki, Sundeep; Barnes, Gareth R.; Penny, William D.. - : Oxford University Press, 2013 BASE Show details 10 The right hemisphere supports but does not replace left hemisphere auditory function in patients with persisting aphasia Teki, Sundeep; Barnes, Gareth R; Penny, William D. - 2013 BASE Show details 11 The right hemisphere supports but does not replace left hemisphere auditory function in patients with persisting aphasia Teki, Sundeep; Barnes, Gareth R.; Penny, William D.. - : Oxford University Press, 2013 BASE Show details 12 An Investigation of Twenty/20 Vision in Reading Hellyer, Peter J.; Woodhead, Zoé V. J.; Leech, Robert. - : Society for Neuroscience, 2011 BASE Show details 13 The visual word form system in context Woodhead, Zoe V. J.; Brownsett, Sonia L. E.; Dhanjal, Novraj S.. - : Society for Neuroscience, 2011 BASE Show details

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