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Innate immunity impacts social-cognitive functioning in people with multiple sclerosis and healthy individuals: Implications for IL-1ra and urinary immune markers
In: Brain Behav Immun Health (2021)
Abstract: Social-cognitive difficulties can negatively impact interpersonal communication, shared social experience, and meaningful relationships. This pilot investigation examined the relationship between social-cognitive functioning and inflammatory markers in people with multiple sclerosis (MS) and demographically-matched healthy individuals. Additionally, we compared the immune marker profile in serum and urine-matched samples. Social cognitive functioning was objectively assessed using The Awareness of Social Inference Test – Short (TASIT-S) and subjectively assessed using self-reports of abilities in emotion recognition, emotional empathy, and cognitive theory of mind. In people with MS and healthy individuals, there were moderate-to-large negative relationships between pro-inflammatory biomarkers (serum IL-1β, IL-17, TNF-α, IP-10, MIP-1α, and urine IP-10, MIP-1β) of the innate immune system and social-cognitive functioning. In MS, a higher serum concentration of the anti-inflammatory marker IL-1ra was associated with better social-cognitive functioning (i.e., self-reported emotional empathy and TASIT-S sarcasm detection performance). However, there were mixed findings for anti-inflammatory serum markers IL-4 and IL-10. Overall, our findings indicate a relationship between pro-inflammatory cytokines and social-cognitive abilities. Future studies may provide greater insight into biologically-derived inflammatory processes, sickness behaviour, and their connection with social cognition.
Keyword: Full Length Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8474509/
http://www.ncbi.nlm.nih.gov/pubmed/34589763
https://doi.org/10.1016/j.bbih.2021.100254
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2
Discourse recovery after severe traumatic brain injury: exploring the first year
In: Brain Inj (2019)
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3
Discourse recovery after severe traumatic brain injury : exploring the first year
Elbourn, Elise; Kenny, Belinda J. (R19919); Power, Emma. - : U.K., Taylor & Francis, 2019
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4
Procedural discourse performance in adults with severe traumatic brain injury at 3 and 6 months post injury
In: Brain Inj (2018)
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5
Procedural discourse performance in adults with severe traumatic brain injury at 3 and 6 months post injury
Stubbs, Elin; Togher, Leanne; Kenny, Belinda J. (R19919). - : U.K., Taylor & Francis, 2018
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6
Cognitive-communication and psychosocial functioning 12 months after severe traumatic brain injury
Tran, Sarah; Kenny, Belinda J. (R19919); Power, Emma. - : U.K., Taylor & Francis, 2018
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7
Conversational topics discussed by individuals with severe traumatic brain injury and their communication partners during sub-acute recovery
In: Brain Inj (2016)
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8
Conversational topics discussed by individuals with severe traumatic brain injury and their communication partners during sub-acute recovery
Brassel, Sophie; Kenny, Belinda J. (R19919); Power, Emma. - : U.K., Taylor & Francis, 2016
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9
The Single-Case Reporting Guideline In BEhavioural Interventions (SCRIBE) 2016 Statement
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10
The Single-Case Reporting guideline In BEhavioural interventions (SCRIBE) 2016 statement
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11
Social and communication disorders following traumatic brain injury
Togher, Leanne (Hrsg.); McDonald, Skye (Hrsg.); Code, Christopher (Hrsg.). - London [u.a.] : Psychology Press, 2013
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UB Frankfurt Linguistik
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12
Measuring the social interactions of people with traumatic brain injury and their communication partners: the adapted Kagan scales
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 24 (2010) 6-8, 914-927
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OLC Linguistik
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13
The methodological quality of aphasia therapy research: an investigation of group studies using the PsycBITE evidence-based practice database
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 23 (2009) 6, 694-706
BLLDB
OLC Linguistik
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14
The methodological quality of aphasia therapy research: An investigation of group studies using the PsycBITETM evidence-based practice database
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 23 (2008) 6, 694-706
OLC Linguistik
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15
Neuropsychological studies of sarcasm
In: Irony in language and thought (New York, NY, 2007), p. 217-230
MPI für Psycholinguistik
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16
The social and neuropsychological underpinnings of communication disorders after severe traumatic brain injury
In: Clinical aphasiology. - Hove [u.a.] : Psychology Press (2007), 42-71
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17
The methodological quality of aphasia research: an investigation using the PsycBITE™ database
BASE
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18
Improving evidence-based practice in rehabilitation : introducing PsycBITE
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 20 (2006) 7, 676-683
BLLDB
OLC Linguistik
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19
Evaluating the causes of impaired irony comprehension following traumatic brain injury
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 19 (2005) 8, 712-730
BLLDB
OLC Linguistik
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20
Training communication partners of people with traumatic brain injury: A randomised controlled trial
In: Aphasiology. - London [u.a.] : Routledge, Taylor & Francis Group 18 (2004) 4, 313-336
OLC Linguistik
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