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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. ...
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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.
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Speech production differences in English and Italian speakers with nonfluent variant PPA
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In: Neurology (2020)
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The clinico-metabolic correlates of language impairment in corticobasal syndrome and progressive supranuclear palsy
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In: ISSN: 2213-1582 ; NeuroImage: Clinical (2019) P. 102009 (2019)
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Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
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In: Cortex (2019)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://hal-univ-fcomte.archives-ouvertes.fr/hal-03630161 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Prevalence of amyloid‐β pathology in distinct variants of primary progressive aphasia
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Bergeron, David; Gorno-Tempini, Maria,; Rabinovici, Gil,; Santos-Santos, Miguel,; Seeley, William; Miller, Bruce,; Pijnenburg, Yolande; Keulen, M Antoinette; Groot, Colin; Van Berckel, Bart,; Van Der Flier, Wiesje,; Scheltens, Philip; Rohrer, Jonathan,; Warren, Jason,; Schott, Jonathan,; Fox, Nick,; Sánchez-Valle, Raquel; Grau-Rivera, Oriol; Gelpi, Ellen; Seelaar, Harro; Papma, Janne,; Van Swieten, John,; Hodges, John,; Leyton, Cristian,; Piguet, Olivier; Rogalski, Emily,; Mesulam, Marsel,; Koric, Lejla; Nora, Kristensen; Pariente, Jeéreémie; Dickerson, Bradford; Mackenzie, Ian,; Hsiung, Ging-Yuek,; Belliard, Serge; Irwin, David,; Wolk, David,; Grossman, Murray; Jones, Matthew; Harris, Jennifer; Mann, David; Snowden, Julie,; Chrem-Mendez, Patricio; Calandri, Ismael,; Amengual, Alejandra,; Miguet-Alfonsi, Carole; Magnin, Eloi; Magnani, Giuseppe; Santangelo, Roberto; Deramecourt, Vincent; Pasquier, Florence; Mattsson, Niklas; Nilsson, Christer; Hansson, Oskar; Keith, Julia; Masellis, Mario; Black, Sandra,; Matías-Guiu, Jordi,; Cabrera-Martin, María-Nieves; Paquet, Claire; Dumurgier, Julien; Teichmann, Marc; Sarazin, Marie; Bottlaender, Michel; Dubois, Bruno; Rowe, Christopher,; Villemagne, Victor,; Vandenberghe, Rik; Granadillo, Elias; Teng, Edmond; Mendez, Mario; Meyer, Philipp,; Frings, Lars; Lleó, Alberto; Blesa, Rafael; Fortea, Juan; Seo, Sang Won; Diehl-Schmid, Janine; Grimmer, Timo; Frederiksen, Kristian Steen; Sánchez-Juan, Pascual; Chételat, Gaël; Jansen, Willemijn; Bouchard, Rémi,; Laforce, Robert Jr; Visser, Pieter Jelle; Ossenkoppele, Rik
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In: ISSN: 0364-5134 ; EISSN: 1531-8249 ; Annals of Neurology ; https://www.hal.inserm.fr/inserm-02749861 ; Annals of Neurology, Wiley, 2018, 84 (5), pp.729-740. ⟨10.1002/ana.25333⟩ (2018)
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Abstract:
International audience ; Objective: To estimate the prevalence of amyloid positivity, defined by positron emission tomography (PET)/cerebrospinal fluid (CSF) biomarkers and/or neuropathological examination, in primary progressive aphasia (PPA) variants.Methods: We conducted a meta-analysis with individual participant data from 1,251 patients diagnosed with PPA (including logopenic [lvPPA, n = 443], nonfluent [nfvPPA, n = 333], semantic [svPPA, n = 401], and mixed/unclassifiable [n = 74] variants of PPA) from 36 centers, with a measure of amyloid-β pathology (CSF [n = 600], PET [n = 366], and/or autopsy [n = 378]) available. The estimated prevalence of amyloid positivity according to PPA variant, age, and apolipoprotein E (ApoE) ε4 status was determined using generalized estimating equation models.Results: Amyloid-β positivity was more prevalent in lvPPA (86%) than in nfvPPA (20%) or svPPA (16%; p < 0.001). Prevalence of amyloid-β positivity increased with age in nfvPPA (from 10% at age 50 years to 27% at age 80 years, p < 0.01) and svPPA (from 6% at age 50 years to 32% at age 80 years, p < 0.001), but not in lvPPA (p = 0.94). Across PPA variants, ApoE ε4 carriers were more often amyloid-β positive (58.0%) than noncarriers (35.0%, p < 0.001). Autopsy data revealed Alzheimer disease pathology as the most common pathologic diagnosis in lvPPA (76%), frontotemporal lobar degeneration-TDP-43 in svPPA (80%), and frontotemporal lobar degeneration-TDP-43/tau in nfvPPA (64%).Interpretation: This study shows that the current PPA classification system helps to predict underlying pathology across different cohorts and clinical settings, and suggests that age and ApoE genotype should be considered when interpreting amyloid-β biomarkers in PPA patients. Ann Neurol 2018;84:737-748.
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Keyword:
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
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URL: https://doi.org/10.1002/ana.25333 https://www.hal.inserm.fr/inserm-02749861
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Prevalence of Amyloid-β Pathology in Distinct Variants of Primary Progressive Aphasia
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Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia: Amyloid-β Pathology in PPA
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In: Annals of Neurology. - 84, 5 (2018) , 729-740, ISSN: 0364-5134 (2018)
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The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia
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The Role of Single-Subject Brain Metabolic Patterns in the Early Differential Diagnosis of Primary Progressive Aphasias and in Prediction of Progression to Dementia
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A multimodal neuroimaging study of a case of crossed nonfluent/agrammatic primary progressive aphasia
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The Semantic Variant of Primary Progressive Aphasia: Clinical and Neuroimaging Evidence in Single Subjects
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In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology
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In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology
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Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology.
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In: Behavioural neurology, vol 26, iss 1-2 (2013)
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Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick’s disease pathology
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