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Observation of new excited ${B} ^0_{s} $ states
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In: Eur.Phys.J.C ; https://hal.archives-ouvertes.fr/hal-03010999 ; Eur.Phys.J.C, 2021, 81 (7), pp.601. ⟨10.1140/epjc/s10052-021-09305-3⟩ (2021)
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Follow-Up in Aphasia Caused by Acute Stroke in a Prospective, Randomized, Clinical, and Experimental Controlled Noninvasive Study With an iPad-Based App (Neolexon®): Study Protocol of the Lexi Study
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Feil, Katharina; Erbert, Franziska; Dieterich, Marianne; Müller, Katharina; Young, Peter; Becker, Regina; Lehner, Katharina; Pfahler, Angelika; Kellert, Lars; Rheinwald, Marika; Thunstedt, Dennis C.; Kuepper, Clemens
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In: Frontiers in Neurology (2020)
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Abstract:
Rationale: Treatment of aphasia is still challenging for clinicians and patients. So far, there is proven evidence for “face-to-face” speech therapy. However, the digital age potentially offers new and complementary strategies that may add to treatment outcome in a cost-effective way. Neolexon® is a commercial tablet-based software for treatment of aphasia, which can be applied with the help of a therapist or as self-training by the patient. Aims and hypothesis: In the Lexi study, we aim to determine whether treatment with Neolexon® is superior to standard therapy in acute post-stroke aphasia. Sample size estimates: A sample size of 180 patients, 90 for each group, will be included with an assumed dropout rate of ~20%. Methods and design: Prospective, randomized, parallel group, open-label, blinded-endpoint clinical, and experimental controlled non-invasive trial (PROBE). Adult German native speakers with acute aphasia after stroke are included. Computer-generated, blocked, and stratified randomization by aphasia severity will assign patients to one of two groups: 4 weeks of either standard logopedic speech therapy or logopedic speech therapy with the app version of Neolexon®. Both groups will be instructed in self-training: the frequency and duration of self-training will be documented. Screening for aphasia will be performed using the Language Screening Test (LAST). The severity of aphasia in general and in subitems will be assessed using the Bielefelder Aphasie Screening (BIAS) and the Aphasia Check List (ACL). Follow-up will be assessed after 3 months. Study outcomes: Based on the consensus in our study team, we considered a 10% mean difference in the change of percentile rank (PR) of BIAS to be a minimal and clinically important difference. The primary endpoint is defined as a significant difference in BIAS comparing the two groups. Differences in quality of life, Beck Depression Inventory (BDI), and modified Ranking Scale (mRS) will be evaluated as secondary outcome parameters. Discussion: This trial will determine whether speech therapy with the use of Neolexon® is superior to standard logopedic therapy. Subgroups with the greatest response to Neolexon® will be described. The trial was prospectively registered on the “EU Clinical Trials Register” (NCT04080817).
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Keyword:
ddc:610; Medizin
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URL: https://epub.ub.uni-muenchen.de/87451/
http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-87451-1
https://epub.ub.uni-muenchen.de/87451/1/fneur-11-00294.pdf
https://doi.org/10.3389/fneur.2020.00294
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Follow-Up in Aphasia Caused by Acute Stroke in a Prospective, Randomized, Clinical, and Experimental Controlled Noninvasive Study With an iPad-Based App (Neolexon®): Study Protocol of the Lexi Study
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In: Front Neurol (2020)
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Observation of $B^0_s\to\bar{D}^0 K^0_S$ and evidence for $B^0_s\to\bar{D}^{*0} K^0_S$ decays
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Zum Geleit: Kosmopolitismus & Körperlichkeit im 18. Jahrhundert im Drama und auf der Bühne – in Kopenhagen und anderswo
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Kosmopolitismus & Körperlichkeit im europäischen Drama des 18. Jahrhunderts
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Der Bühnenbrief: Verhandlungen von Körperlichkeit und Epistolarizität auf der Bühne des 18. Jahrhunderts
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Cosmopolitan Interventions on the late Eighteenth-Century Stage
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