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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. ...
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Sensitivity and specificity of an acoustic- and perceptual-based tool for assessing motor speech disorders in French: the MonPaGe -screening protocol
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In: ISSN: 0269-9206 ; EISSN: 1464-5076 ; Clinical Linguistics & Phonetics ; https://hal.archives-ouvertes.fr/hal-03099545 ; Clinical Linguistics & Phonetics, Taylor & Francis, In press, ⟨10.1080/02699206.2020.1865460⟩ (2021)
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Analysing spectral changes over time to identify articulatory impairments in dysarthria
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In: ISSN: 0001-4966 ; EISSN: 1520-8524 ; Journal of the Acoustical Society of America ; https://hal.archives-ouvertes.fr/hal-03099517 ; Journal of the Acoustical Society of America, Acoustical Society of America, 2021, 149 (2), pp.758 - 769. ⟨10.1121/10.0003332⟩ (2021)
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Neurocognitive course at two-year follow-up in the neurocognitive assessment in the metabolic and aging cohort (NAMACO) study. ...
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Analysing spectral changes over time to identify articulatory impairments in dysarthria
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In: ISSN: 0001-4966 ; Journal of the Acoustical Society of America, Vol. 149, No 2 (2021) pp. 758-769 (2021)
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Sensitivity and specificity of an acoustic- and perceptual-based tool for assessing motor speech disorders in French: the MonPaGe-screening protocol
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In: ISSN: 0269-9206 ; Clinical Linguistics and Phonetics (2021) pp. 1-16 (2021)
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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.
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Neurocognitive course at 2-year follow-up in a Swiss cohort of people with well-treated HIV
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Damas, José; Ledergerber, Bruno; Nadin, Isaure; Tarr, Philip E.; Stoeckle, Marcel; Kunze, Ursi; Hauser, Christoph; Gutbrod, Klemens; Calmy, Alexandra; Assal, Frédéric; Schmid, Patrick; Hundsberger, Thomas; Di Benedetto, Caroline; Rossi, Stefania; Hasse, Barbara; Schlosser, Ladina; Pasquier, Renaud Du; Darling, Katharine E.A.; Cavassini, Matthias
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In: AIDS (2021)
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Abstract:
OBJECTIVE: The aim of this study was to examine neurocognitive course over time among people with well treated HIV. DESIGN: The Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study is an ongoing, prospective, longitudinal, multicenter and multilingual study within the Swiss HIV Cohort Study (SHCS). Participants undergo neuropsychological assessment at baseline and two-yearly follow-up. SETTING: Seven SHCS centres. PARTICIPANTS: Patients aged at least 45 years enrolled in the SHCS with fluency in the local language (French, German or Italian) and agreeing to participate in the NAMACO study: 981 participants at baseline, 720 at 2-year follow-up of whom 644 had complete data sets. INTERVENTION: Standardized neuropsychological assessment at baseline and 2-year follow-up. MAIN OUTCOME MEASURE: Neurocognitive performance using Frascati criteria and mean z-scores. RESULTS: Four participants (of 644, 0.6%) had plasma HIV-1 RNA more than 50 copies/ml; median CD4(+) cell count was 660 cells/μl. According to Frascati criteria, 204 participants (31.7%) had neurocognitive impairment (NCI) at baseline. NCI severity in these participants changed little over 2 years and comprehensive models based on Frascati criteria were not feasible. Examining mean z-scores, however, we observed neurocognitive stability or improvement over two years in five of seven neurocognitive domains assessed. Age at least 65 years (P = 0.02) and cognitive complaints (P = 0.004) were associated with neurocognitive decline, while black race (P = 0.01) and dolutegravir treatment (P = 0.002) were associated with improvement. CONCLUSION: Frascati criteria were less sensitive in measuring NCI change and therefore unsuitable for following neurocognitive course in our cohort of people with well treated HIV. Examining neurocognitive course by mean z-score change, we observed stability or improvement.
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Clinical Science
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8631148/
http://www.ncbi.nlm.nih.gov/pubmed/34411034
https://doi.org/10.1097/QAD.0000000000003057
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MonPaGe, un outil de screening francophone informatisé d’évaluation perceptive et acoustique des troubles moteurs de la parole (dysarthries, apraxie de la parole
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In: ISSN: 0034-222X ; Rééducation orthophonique ; https://halshs.archives-ouvertes.fr/halshs-02504027 ; Rééducation orthophonique, Ortho édition, 2020, 281, pp.171-197 (2020)
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Impairment of both languages in late bilinguals with dementia of the Alzheimer type
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Second language performances in elderly bilinguals and individuals with dementia: The role of L2 immersion
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Impairment of both languages in late bilinguals with dementia of the Alzheimer type
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Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration
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Progressive Crossed-Apraxia of Speech as a First Manifestation of a Probable Corticobasal Degeneration
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In: ISSN: 0953-4180 ; Behavioural Neurology, Vol. 25, No 4 (2012) pp. 285-289 (2012)
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