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GatorTron: A Large Clinical Language Model to Unlock Patient Information from Unstructured Electronic Health Records ...
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Applications of Explainable Artificial Intelligence in Diagnosis and Surgery
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In: Diagnostics; Volume 12; Issue 2; Pages: 237 (2022)
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The Effect of on Educational Technology on EFL Learners’ Self-Efficacy
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In: Front Psychol (2022)
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The cuff leak test in critically ill patients: An international survey of intensivists
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In: ISSN: 0001-5172 ; EISSN: 1399-6576 ; Acta Anaesthesiologica Scandinavica ; https://hal.archives-ouvertes.fr/hal-03401785 ; Acta Anaesthesiologica Scandinavica, Wiley, 2021, 65 (8), pp.1087-1094. ⟨10.1111/aas.13838⟩ (2021)
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An End-to-End Progressive Multi-Task Learning Framework for Medical Named Entity Recognition and Normalization ...
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A Language Model-based Generative Classifier for Sentence-level Discourse Parsing ...
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Target-oriented Fine-tuning for Zero-Resource Named Entity Recognition ...
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The Neural Processing of Vocal Emotion After Hearing Reconstruction in Prelingual Deaf Children: A Functional Near-Infrared Spectroscopy Brain Imaging Study
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In: Front Neurosci (2021)
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The predictive power of saliva electrolytes exceeds that of saliva microbiomes in diagnosing early childhood caries
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In: J Oral Microbiol (2021)
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Developmental consequences of children born from mothers with telbivudine treatment during late pregnancy: A prospective study with 3-year follow-up
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In: Virulence (2021)
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Dynamic methylome of internal mRNA N(7)-methylguanosine and its regulatory role in translation
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In: Cell Res (2019)
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Abstract:
Over 150 types of RNA modifications are identified in RNA molecules. Transcriptome profiling is one of the key steps in decoding the epitranscriptomic panorama of these chemical modifications and their potential functions. N(7)-methylguanosine (m(7)G) is one of the most abundant modifications present in tRNA, rRNA and mRNA 5′cap, and has critical roles in regulating RNA processing, metabolism and function. Besides its presence at the cap position in mRNAs, m(7)G is also identified in internal mRNA regions. However, its transcriptome-wide distribution and dynamic regulation within internal mRNA regions remain unknown. Here, we have established m(7)G individual-nucleotide-resolution cross-linking and immunoprecipitation with sequencing (m(7)G miCLIP-seq) to specifically detect internal mRNA m(7)G modification. Using this approach, we revealed that m(7)G is enriched at the 5′UTR region and AG-rich contexts, a feature that is well-conserved across different human/mouse cell lines and mouse tissues. Strikingly, the internal m(7)G modification is dynamically regulated under both H(2)O(2) and heat shock treatments, with remarkable accumulations in the CDS and 3′UTR regions, and functions in promoting mRNA translation efficiency. Consistently, a PCNA 3′UTR minigene reporter harboring the native m(7)G modification site displays both enriched m(7)G modification and increased mRNA translation upon H(2)O(2) treatment compared to the m(7)G site-mutated minigene reporter (G to A). Taken together, our findings unravel the dynamic profiles of internal mRNA m(7)G methylome and highlight m(7)G as a novel epitranscriptomic marker with regulatory roles in translation.
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Keyword:
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URL: http://www.ncbi.nlm.nih.gov/pubmed/31520064 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889513/ https://doi.org/10.1038/s41422-019-0230-z
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AN EXAMINED LIFE OF A LANGUAGE TEACHER OF CHINESE: AN AUTOETHNOGRAPHIC INVESTIGATION INTO AGENCY
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In: Doctoral Dissertations (2019)
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Additional file 1: of Spatial and temporal clustering analysis of tuberculosis in the mainland of China at the prefecture level, 2005â 2015 ...
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Additional file 1: of Spatial and temporal clustering analysis of tuberculosis in the mainland of China at the prefecture level, 2005â 2015 ...
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A Contrast of L1 Pronominal Usage: Japanese and Mandarin in Oral Narratives
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Zhang, Ying. - : Ohio State University. Libraries, 2018
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Telerehabilitation Combined Speech-Language and Cognitive Training Effectively Promoted Recovery in Aphasia Patients
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Une nouvelle architecture intégrant les données lexicales générales, terminologiques et « situées » : Pivax-3
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In: Terminology & Ontology: Theories and applications TOTh 2017 ; https://hal.archives-ouvertes.fr/hal-01712276 ; Terminology & Ontology: Theories and applications TOTh 2017, Jun 2017, Chambéry, France (2017)
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明代職官中英辭典 Chinese-English Dictionary of Ming Government Official Titles
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明代職官中英辭典 Chinese-English Dictionary of Ming Government Official Titles
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In: Zhang, Ying; Xue, Susan; Xue, Zhaohui; & Ni, Li. (2017). 明代職官中英辭典 Chinese-English Dictionary of Ming Government Official Titles. UC Irvine: UC Irvine Libraries. Retrieved from: http://www.escholarship.org/uc/item/2bz3v185 (2017)
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