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Lesion-site-dependent responses to therapy after aphasic stroke
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| 2 |
Less is more: neural mechanisms underlying anomia treatment in chronic aphasic patients.
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| 3 |
Auditory training changes temporal lobe connectivity in ‘Wernicke’s aphasia’: a randomised trial
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| 4 |
Four functionally distinct regions in the left supramarginal gyrus support word processing
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| 5 |
Why the left posterior inferior temporal lobe is needed for word finding
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In: BRAIN , 139 pp. 2823-2826. (2016) (2016)
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| 6 |
Four Functionally Distinct Regions in the Left Supramarginal Gyrus Support Word Processing
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In: CEREBRAL CORTEX , 26 (11) pp. 4212-4226. (2016) (2016)
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| 7 |
Comparing language outcomes in monolingual and bilingual stroke patients.
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In: Brain , 138 (Pt 4) 1070 - 1083. (2015) (2015)
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| 8 |
A Trade-Off between Somatosensory and Auditory Related Brain Activity during Object Naming But Not Reading.
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In: J Neurosci , 35 (11) 4751 - 4759. (2015) (2015)
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| 9 |
Plasticity of white matter connectivity in phonetics experts
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In: Brain Structure and Function (2015) (In press). (2015)
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| 10 |
Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study.
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In: Front Hum Neurosci , 8 , Article 24 . (2014) (2014)
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| 11 |
Inter- and intrahemispheric connectivity differences when reading Japanese Kanji and Hiragana.
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In: Cereb Cortex , 24 (6) pp. 1601-1608. (2014) (2014)
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| 12 |
The importance of premotor cortex for supporting speech production after left capsular-putaminal damage.
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In: J Neurosci , 34 (43) 14338 - 14348. (2014) (2014)
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| 13 |
Dissecting the functional anatomy of auditory word repetition.
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In: Front Hum Neurosci , 8 , Article 246 . (2014) (2014)
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| 14 |
Perturbation of the left inferior frontal gyrus triggers adaptive plasticity in the right homologous area during speech production.
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In: Proc Natl Acad Sci U S A , 110 (41) 16402 - 16407. (2013) (2013)
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Abstract:
The role of the right hemisphere in aphasia recovery after left hemisphere damage remains unclear. Increased activation of the right hemisphere has been observed after left hemisphere damage. This may simply reflect a release from transcallosal inhibition that does not contribute to language functions. Alternatively, the right hemisphere may actively contribute to language functions by supporting disrupted processing in the left hemisphere via interhemispheric connections. To test this hypothesis, we applied off-line continuous theta burst stimulation (cTBS) over the left inferior frontal gyrus (IFG) in healthy volunteers, then used functional MRI to investigate acute changes in effective connectivity between the left and right hemispheres during repetition of auditory and visual words and pseudowords. In separate sessions, we applied cTBS over the left anterior IFG (aIFG) or posterior IFG (pIFG) to test the anatomic specificity of the effects of cTBS on speech processing. Compared with cTBS over the aIFG, cTBS over the pIFG suppressed activity in the left pIFG and increased activity in the right pIFG during pseudoword vs. word repetition in both modalities. This effect was associated with a stronger facilitatory drive from the right pIFG to the left pIFG during pseudoword repetition. Critically, response became faster as the influence of the right pIFG on left pIFG increased, indicating that homologous areas in the right hemisphere actively contribute to language function after a focal left hemisphere lesion. Our findings lend further support to the notion that increased activation of homologous right hemisphere areas supports aphasia recovery after left hemisphere damage.
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Keyword:
Adaptation; Adult; Broca's area; dynamic causal modeling; Female; Frontal Lobe; Germany; Humans; Language; Magnetic Resonance Imaging; Male; Neuronal Plasticity; Physiological; Reaction Time; Speech; transcranial magnetic stimulation; virtual lesion
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URL: http://discovery.ucl.ac.uk/1422009/
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| 15 |
Functionally distinct contributions of the anterior and posterior putamen during sublexical and lexical reading.
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In: Front Hum Neurosci , 7 , Article 787 . (2013) (2013)
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| 16 |
Predicting outcome and recovery after stroke with lesions extracted from MRI images
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In: NEUROIMAGE-CLINICAL , 2 pp. 424-433. (2013) (2013)
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| 17 |
Lesions impairing regular versus irregular past tense production
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In: NeuroImage: Clinical , 3 438 - 449. (2013) (2013)
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| 19 |
Auditory-motor interactions for the production of speech in native and non-native speech
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In: The Journal of Neuroscience , 33 (6) pp. 2376-2387. (2013) (2013)
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| 20 |
Reading without the left ventral occipito-temporal cortex.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2012)
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