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Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: The RELEASE database of aphasia after stroke
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In: Research outputs 2014 to 2021 (2022)
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Utilising a systematic review-based approach to create a database of individual participant data for meta- and network meta-analyses: the RELEASE database of aphasia after stroke
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In: ISSN: 0268-7038 ; EISSN: 1464-5041 ; Aphasiology ; https://hal.archives-ouvertes.fr/hal-03528818 ; Aphasiology, Taylor & Francis (Routledge), 2021, ⟨10.1080/02687038.2021.1897081⟩ (2021)
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Predictors of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis
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In: ISSN: 0039-2499 ; EISSN: 1524-4628 ; Stroke ; https://hal.archives-ouvertes.fr/hal-03277820 ; Stroke, American Heart Association, 2021, 52 (5), pp.1778-1787. ⟨10.1161/strokeaha.120.031162⟩ (2021)
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Predictors of poststroke aphasia recovery: a systematic review-informed individual participant data meta-analysis
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Predictors of Poststroke Aphasia Recovery: A Systematic Review-Informed Individual Participant Data Meta-Analysis ...
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Predictors of Poststroke Aphasia Recovery A Systematic Review-Informed Individual Participant Data Meta-Analysis
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RELEASE: A protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
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In: Research outputs 2014 to 2021 (2020)
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RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
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RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia
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Multisession transcranial direct current stimulation facilitates verbal learning and memory consolidation in young and older adults
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Constraint-induced or multi-modal personalized aphasia rehabilitation (COMPARE): A randomized controlled trial for stroke-related chronic aphasia
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In: Research outputs 2014 to 2021 (2019)
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Neuroplasticity and aphasia treatments: new approaches for an old problem
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Neuroplasticity and aphasia treatments: new approaches for an old problem
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In: J Neurol Neurosurg Psychiatry (2019)
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Transcranial Direct Current Stimulation to Enhance Training Effectiveness in Chronic Post-Stroke Aphasia: A Randomized Controlled Trial Protocol
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Neuroplasticity and aphasia treatments: New approaches for an old problem
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The shape of things to come in speech production: a functional magnetic resonance imaging study of visual form interference during lexical access
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Constraint-induced or multi-modal personalized aphasia rehabilitation (COMPARE): a randomized controlled trial for stroke-related chronic aphasia
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Transcranial direct current stimulation to enhance training effectiveness in chronic post-stroke aphasia: A randomized controlled trial protocol
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Stahl, Benjamin; Darkow, Robert; von Podewils, Viola; Meinzer, Marcus; Grittner, Ulrike; Reinhold, Thomas; Grewe, Tanja; Breitenstein, Caterina; Flöel, Agnes. - : Frontiers Research Foundation, 2019
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Abstract:
Background: Intensive speech-language therapy (SLT) can promote recovery from chronic post-stroke aphasia, a major consequence of stroke. However, effect sizes of intensive SLT are moderate, potentially reflecting a physiological limit of training-induced progress. Transcranial direct current stimulation (tDCS) is an easy-to-use, well-tolerated and low-cost approach that may enhance effectiveness of intensive SLT. In a recent phase-II randomized controlled trial, 26 individuals with chronic post-stroke aphasia received intensive SLT combined with anodal-tDCS of the left primary motor cortex (M1), resulting in improved naming and proxy-rated communication ability, with medium-to-large effect sizes. Aims: The proposed protocol seeks to establish the incremental benefit from anodal-tDCS of M1 in a phase-III randomized controlled trial with adequate power, ecologically valid outcomes, and evidence-based SLT. Methods: The planned study is a prospective randomized placebo-controlled (using sham-tDCS), parallel-group, double-blind, multi-center, phase-III superiority trial. A sample of 130 individuals with aphasia at least 6 months post-stroke will be recruited in more than 18 in-and outpatient rehabilitation centers. Outcomes: The primary outcome focuses on communication ability in chronic post-stroke aphasia, as revealed by changes on the Amsterdam-Nijmegen Everyday Language Test (A-scale; primary endpoint: 6-month follow-up; secondary endpoints: immediately after treatment, and 12-month follow-up). Secondary outcomes include measures assessing linguistic-executive skills, attention, memory, emotional well-being, quality of life, health economic costs, and adverse events (endpoints: 6-month follow-up, immediately after treatment, and 12-month follow-up). Discussion: Positive results will increase the quality of life for persons with aphasia and their families while reducing societal costs. After trial completion, a workshop with relevant stakeholders will ensure transfer into best-practice guidelines and successful integration within clinical routine. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03930121.
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Keyword:
2728 Clinical Neurology; 2808 Neurology; Chronic post-stroke aphasia; Intensive speech-language therapy; Randomized controlled trial; Rehabilitation; Transcranial direct current stimulation
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URL: https://espace.library.uq.edu.au/view/UQ:19ecb98
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Tidier descriptions of speech and language therapy interventions for people with aphasia; consensus from the release collaboration
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In: Research outputs 2014 to 2021 (2018)
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High-definition tDCS of the temporo-parietal cortex enhances access to newly learned words
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