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Managing school interaction networks during the COVID-19 pandemic: Agent-based modeling for evaluating possible scenarios when students go back to classrooms
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In: PLoS One (2021)
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The Relation Between Parent Competence and Parent-Child Interaction: Consideration of Culture
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The use of Wordclouds for vocabulary retention in the English for Psychology classroom
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Spanish Translation, Cultural Adaptation, and Validation of the Standardized Cosmesis and Health Nasal Outcomes Survey Questionnaire
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A Dual Interaction Between the 5 '- and 3 '-Ends of the Melon Necrotic Spot Virus (MNSV) RNA Genome Is Required for Efficient Cap-Independent Translation
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Abstract:
Frontiers and its users benefit from a Creative Commons CC-BY licence over all content. ; In eukaryotes, the formation of a 5'-cap and 3'-poly(A) dependent protein-protein bridge is required for translation of its mRNAs. In contrast, several plant virus RNA genomes lack both of these mRNA features, but instead have a 3'-CITE (for cap-independent translation enhancer), a RNA element present in their 3'-untranslated region that recruits translation initiation factors and is able to control its cap-independent translation. For several 3'-CITEs, direct RNA-RNA long-distance interactions based on sequence complementarity between the 5'- and 3'-ends are required for efficient translation, as they bring the translation initiation factors bound to the 3'-CITE to the 5'-end. For the carmovirus melon necrotic spot virus (MNSV), a 3'-CITE has been identified, and the presence of its 5'-end in cis has been shown to be required for its activity. Here, we analyze the secondary structure of the 5'-end of the MNSV RNA genome and identify two highly conserved nucleotide sequence stretches that are complementary to the apical loop of its 3'-CITE. In in vivo cap-independent translation assays with mutant constructs, by disrupting and restoring sequence complementarity, we show that the interaction between the 3'-CITE and at least one complementary sequence in the 5'-end is essential for virus RNA translation, although efficient virus translation and multiplication requires both connections. The complementary sequence stretches are invariant in all MNSV isolates, suggesting that the dual 5'-3' RNA: RNA interactions are required for optimal MNSV cap-independent translation and multiplication. ; This work was supported by grants AGL2009-07552/AGR, AGL2015-72804-EXP, and AGL2015-65838 (MINECO, Spain) and 19252/PI/2014 (Fundacion Seneca, Spain). AR-H was supported by grants from the National Council of Science and Technology (CONACyT, Mexico) and the Spanish Agency for International Development Cooperation (AECID). MM was recipient of a fellowship from the Spanish Ministerio de Ciencia e Innovacion (BES-2010-032827). ; Peer reviewed
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Keyword:
3 '-CITE; cap-independent translation; MNSV; plant virus; RNA structure; RNA: RNA interactions; translation initiation; translational enhancer
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URL: http://hdl.handle.net/10261/181451
https://doi.org/10.13039/501100003329
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| 6 |
Un autoanálisis crítico para docentes de la enseñanza bilingüe: Ideología, pedagogía, acceso y equidad (IPAE)
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In: Revista de Sociología de la Educación-RASE; Vol. 11, Núm. 3 (2018): MEDIOS DE COMUNICACIÓN, SOCIEDAD Y EDUCACIÓN; 487-496 ; 2605-1923 (2018)
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Un autoanálisis crítico para docentes de la enseñanza bilingüe : Ideología, pedagogía, acceso y equidad (IPAE)
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In: Alfaro, Cristina ; Hernández, Ana. Un autoanálisis crítico para docentes de la enseñanza bilingüe : Ideología, pedagogía, acceso y equidad (IPAE). En: Revista de Sociología de la Educación-RASE, 11 3 2018: 487-496 (2018)
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| 8 |
A Dual Interaction Between the 5′- and 3′-Ends of the Melon Necrotic Spot Virus (MNSV) RNA Genome Is Required for Efficient Cap-Independent Translation
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| 9 |
Hispanohablantes en el mapa rural de Georgia: datos demográficos, uso de inglés y español y la necesidad de un estudio sobre prácticas lingüísticas en la región del Medio -Atlántico.
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In: South East Coastal Conference on Languages & Literatures (SECCLL) (2016)
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| 10 |
La intención emprendedora de los investigadores universitarios: el caso de las "spin-off" académicas
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La intención emprendedora de los investigadores universitarios: el caso de las "spin-off" académicas
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| 12 |
The promotion of health and beauty tourism through websites a linguistic analysis
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In: LFE. Revista de lenguas para fines específicos [eISSN 2340-8561], v. 22 (2), p. 62-83 (2016)
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Hacia una internacionalización del sistema de enseñanza español: la enseñanza bilingüe francés-español
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| 14 |
Teoría universalista de Jakobson y orden de adquisición de los fonemas consonánticos del español mexicano: estudio de caso
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In: Onomázein: Revista de lingüística, filología y traducción de la Pontificia Universidad Católica de Chile, ISSN 0717-1285, Nº. 34, 2016, pags. 1-7 (2016)
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| 15 |
The promotion of health and beauty tourism through websites: a linguistic analysis
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In: LFE: Revista de lenguas para fines específicos, ISSN 1133-1127, Vol. 22, Nº 2, 2016, pags. 62-83 (2016)
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| 17 |
Easy-to-read Texts for Students with Intellectual Disability: Linguistic Factors Affecting Comprehension
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Successes and challenges of instructional strategies in two-way bilingual immersion
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In: Hernández, Ana Margarita. (2011). Successes and challenges of instructional strategies in two-way bilingual immersion. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2kw1b2w1 (2011)
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