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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium.
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
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Miyagawa, Toji; Brushaber, Danielle; Syrjanen, Jeremy; Kremers, Walter; Fields, Julie; Forsberg, Leah K; Heuer, Hilary W; Knopman, David; Kornak, John; Boxer, Adam; Rosen, Howie; Boeve, Bradley; ARTFL/LEFFTDS Consortium
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association, vol 16, iss 1 (2020)
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Abstract:
IntroductionBehavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD).MethodsWe analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium.ResultsThe CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB)=0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders.DiscussionThe BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.
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Keyword:
Acquired Cognitive Impairment; Adult; Aged; Aging; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer's Disease Related Dementias (ADRD); ARTFL/LEFFTDS Consortium; Behavior; Behavioral and Social Science; Brain Disorders; CDR; CDR®; Clinical Research; Clinical Sciences; Comportment and personality; Cross-Sectional Studies; Dementia; Female; Frontotemporal Dementia; Frontotemporal Dementia (FTD); Frontotemporal Lobar Degeneration; Geriatrics; Humans; Language; Mental Status and Dementia Tests; Middle Aged; NACC FTLD Module; Neurodegenerative; Neurosciences; Personality; Primary progressive aphasia; Primary progressive aphasia Language; Rare Diseases
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URL: https://escholarship.org/uc/item/6np868k1
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Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium
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In: Alzheimers Dement (2020)
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Utility of the CDR® plus NACC FTLD in Mild FTLD: Data from the ARTFL/LEFFTDS Consortium
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In: Alzheimers Dement (2020)
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