1 |
Investigating the effects of handedness on the consistency of lateralization for speech production and semantic processing tasks using functional transcranial Doppler sonography
|
|
|
|
BASE
|
|
Show details
|
|
2 |
Testing the unitary theory of language lateralization using functional transcranial Doppler sonography in adults
|
|
|
|
BASE
|
|
Show details
|
|
3 |
CATALISE : a multinational and multidisciplinary Delphi consensus study. Identifying language impairments in children
|
|
|
|
BASE
|
|
Show details
|
|
4 |
CATALISE : a multinational and multidisciplinary Delphi consensus study. Identifying language impairments in children
|
|
|
|
BASE
|
|
Show details
|
|
6 |
Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia
|
|
|
|
BASE
|
|
Show details
|
|
7 |
CNTNAP2 variants affect early language development in the general population
|
|
|
|
Abstract:
Early language development is known to be under genetic influence, but the genes affecting normal variation in the general population remain largely elusive. Recent studies of disorder reported that variants of the CNTNAP2 gene are associated both with language deficits in specific language impairment (SLI) and with language delays in autism. We tested the hypothesis that these CNTNAP2 variants affect communicative behavior, measured at 2 years of age in a large epidemiological sample, the Western Australian Pregnancy Cohort (Raine) Study. Singlepoint analyses of 1149 children (606 males and 543 females) revealed patterns of association which were strikingly reminiscent of those observed in previous investigations of impaired language, centered on the same genetic markers and with a consistent direction of effect (rs2710102, P = 0.0239; rs759178, P = 0.0248). On the basis of these findings, we performed analyses of four-marker haplotypes of rs2710102–rs759178–rs17236239–rs2538976 and identified significant association (haplotype TTAA, P = 0.049; haplotype GCAG, P = .0014). Our study suggests that common variants in the exon 13–15 region of CNTNAP2 influence early language acquisition, as assessed at age 2, in the general population. We propose that these CNTNAP2 variants increase susceptibility to SLI or autism when they occur together with other risk factors.
|
|
Keyword:
Original Articles
|
|
URL: http://www.ncbi.nlm.nih.gov/pubmed/21310003 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130139 https://doi.org/10.1111/j.1601-183X.2011.00684.x
|
|
BASE
|
|
Hide details
|
|
8 |
Overlaps between autism and language impairment: phenomimicry or shared etiology?
|
|
|
|
BASE
|
|
Show details
|
|
9 |
Lower-frequency event-related desynchronization: a signature of late mismatch responses to sounds, which is reduced or absent in children with specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
10 |
Genes, cognition, and communication: insights from neurodevelopmental disorders
|
|
|
|
BASE
|
|
Show details
|
|
13 |
Weak hand preference in children with down syndrome is associated with language deficits
|
|
|
|
BASE
|
|
Show details
|
|
14 |
Weak hand preference in children with Down syndrome is associated with language deficits
|
|
|
|
BASE
|
|
Show details
|
|
15 |
Heritability of specific language impairment depends on diagnostic criteria
|
|
|
|
BASE
|
|
Show details
|
|
16 |
Heritable risk factors associated with language impairments
|
|
|
|
BASE
|
|
Show details
|
|
17 |
Is poor frequency modulation detection linked to literacy problems? A comparison of specific reading disability and mild to moderate sensorineural hearing loss
|
|
|
|
BASE
|
|
Show details
|
|
18 |
Speech and non-speech processing in people with specific language impairment: a behavioural and electrophysiological study
|
|
|
|
BASE
|
|
Show details
|
|
19 |
Frequency discrimination deficits in people with specific language impairment : reliability, validity, and linguistic correlates
|
|
|
|
BASE
|
|
Show details
|
|
|
|