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Alterations to dual stream connectivity predicts response to aphasia therapy following stroke
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Cross-modal emotion recognition and autism-like traits in typically developing children
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An automated approach to examining pausing in the speech of people with dementia
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The influence of contextual constraint on verbal selection mechanisms and its neural correlates in Parkinson’s disease
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Alterations to dual stream connectivity predicts response to aphasia therapy following stroke
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The Suppression of Irrelevant Semantic Representations in Parkinson’s Disease
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Functional correlates of strategy formation and verbal suppression in Parkinson's disease
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Abstract:
Individuals with Parkinson's disease (PD) have shown impaired performance on the verbal suppression component of the Haylings Sentence Completion Test (HSCT). The present study aimed to determine whether this performance related to (i) the inability to suppress a pre-potent response or (ii) difficulty in the generation of a strategy to facilitate task execution. The study adopted a novel variation of the HSCT that isolated each process and employed fMRI to examine the associated neural correlates in a comparison of individuals with PD and matched healthy controls. No significant behavioral differences were detected between these two groups. However, fMRI results revealed atypical underlying neural activity in the PD group. Controls exhibited increased activation in the left dorsolateral prefrontal cortex and striatum when generating a response independently, relative to generation when a supporting strategy was provided. The PD group demonstrated the opposite pattern of activation, in addition to greater recruitment of right hemisphere regions. This pattern of activation was postulated to be evidence of compensatory mechanisms, acting to bolster the output of frontostriatal circuits compromised by disease pathology.
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Keyword:
2728 Clinical Neurology; 2741 Radiology Nuclear Medicine and imaging; 2805 Cognitive Neuroscience; 2808 Neurology; fMRI; Inhibition; Lexical-semantics; Parkinson's disease; Prefrontal cortex
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URL: https://espace.library.uq.edu.au/view/UQ:c3fa346
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Semantic processing in children with cochlear implants: evidence from event-related potentials
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Conversational trouble and repair in dementia: revision of an existing coding framework
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The suppression of irrelevant semantic representations in Parkinson's Disease
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Reading development in children with cochlear implants who communicate via spoken language: A psycholinguistic investigation
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Spelling in children with cochlear implants: evidence of underlying processing differences
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Lexical ambiguity resolution during sentence processing in Parkinson’s disease: An event-related potential study
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Semantic Feature Disturbance in Alzheimer Disease: Evidence from an Object Decision Task
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