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The Role of Morphological Awareness in Listening Comprehension of Chinese Blind Children: The Mediation of Vocabulary Knowledge
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In: Psychol Res Behav Manag (2021)
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LEVERAGING PREDICTIVE ANALYTICS TO ASSESS 7TH FLEET SUSTAINMENT
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Evaluating the granularity and statistical structure of lesions and behaviour in post-stroke aphasia ...
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Evaluating the granularity and statistical structure of lesions and behaviour in post-stroke aphasia
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Abstract:
The pursuit of relating the location of neural damage to the pattern of acquired language and general cognitive deficits post-stroke stems back to 19th century behavioural neurology. Whilst spatial specificity has improved dramatically over time, from the large areas of damage specified by post-mortem investigation to the millimetre precision of modern MRI, there is an underlying issue that is rarely addressed, which relates to the fact that damage to a given area of the brain is not random but constrained by the brain’s vasculature. Accordingly, the aim of this study was to uncover the statistical structure underlying the lesion profile in chronic aphasia post-stroke. By applying varimax-rotated principal component analysis to the lesions of 70 patients with chronic post-stroke aphasia, we identified 17 interpretable clusters, largely reflecting the vascular supply of middle cerebral artery sub-branches and other sources of individual variation in vascular supply as shown in classical angiography studies. This vascular parcellation produced smaller displacement error in simulated lesion-symptom analysis compared with individual voxels and Brodmann regions. A second principal component analysis of the patients’ detailed neuropsychological data revealed a four factor solution reflecting phonological, semantic, executive-demand and speech fluency abilities. As a preliminary exploration, stepwise regression was used to relate behavioural factor scores to the lesion principal components. Phonological ability was related to two components, which covered the posterior temporal region including the posterior segment of the arcuate fasciculus, and the inferior frontal gyrus. Three components were linked to semantic ability and were located in the white matter underlying the anterior temporal lobe, the supramarginal gyrus and angular gyrus. Executive-demand related to two components covering the dorsal edge of the middle cerebral artery territory, while speech fluency was linked to two components that were located in the middle frontal gyrus, precentral gyrus, and subcortical regions (putamen and thalamus). Future studies can explore in formal terms the utility of these PCA-derived lesion components for relating post-stroke lesions and symptoms.
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URL: https://doi.org/10.17863/CAM.52218
https://www.repository.cam.ac.uk/handle/1810/305136
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| 5 |
Evaluating the granularity and statistical structure of lesions and behaviour in post-stroke aphasia
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In: Brain Commun (2020)
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Contributions of morphological awareness and rapid automatized naming (RAN) to Chinese children’s reading comprehension versus reading fluency: evidence from a longitudinal mediation model [<Journal>]
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DNB Subject Category Language
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MV-22 SUPPLY CHAIN AGILITY: A STATIC SUPPLY CHAIN SUPPORTING A DYNAMIC DEPLOYMENT
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Relating resting-state hemodynamic changes to the variable language profiles in post-stroke aphasia
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Using D3 to Visualize Lexical Link Analysis (LLA) and ADS-B Data
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Gomphidictinus tongi Zhang & Guan & Wang 2017, sp. nov. ...
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Gomphidictinus tongi Zhang & Guan & Wang 2017, sp. nov. ...
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Leveraging Lexical Link Analysis (LLA) to discover new knowledge
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Functional Anatomy of Recognition of Chinese Multi-Character Words: Convergent Evidence from Effects of Transposable Nonwords, Lexicality, and Word Frequency
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Diabetes and Hypertension Consistently Predict the Presence and Extent of Coronary Artery Calcification in Symptomatic Patients: A Systematic Review and Meta-Analysis
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Leveraging Lexical Link Analysis (LLA) To Discover New Knowledge
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In: Military Cyber Affairs (2016)
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Cis-regulatory architecture of a brain-signaling center predates the origin of chordates
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Functional Anatomy of Recognition of Chinese Multi-Character Words: Convergent Evidence from Effects of Transposable Nonwords, Lexicality, and Word Frequency
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Lexical Link Analysis Application: Improving Web Service to Acquisition Visibility Portal
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In: DTIC (2014)
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Lexical Link Analysis Application: Improving Web Service to Acquisition Visibility Portal Phase II
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In: DTIC (2014)
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