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Analyzing classroom teacher-student consultations: a systemic-multimodal perspective ...
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Analyzing classroom teacher-student consultations: a systemic-multimodal perspective ...
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Non-routine Mathematical Problem-Solving: Creativity, Engagement, and Intuition of STEM Tertiary Students
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The anesthetic approach for endovascular recanalization therapy depends on the lesion site in acute ischemic stroke
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In: Neuroradiology (2021)
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
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In: Sci Rep (2021)
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Lesion site and therapy time predict responses to a therapy for anomia after stroke: a prognostic model development study
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Lesions that do or do not impair digit span: a study of 816 stroke survivors
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In: Brain Commun (2021)
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Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
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Gajardo-Vidal, Andrea; Lorca-Puls, Diego L; team, PLORAS; Warner, Holly; Pshdary, Bawan; Crinion, Jennifer T; Leff, Alexander P; Hope, Thomas M H; Geva, Sharon; Seghier, Mohamed L; Green, David W; Bowman, Howard; Price, Cathy J
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In: Brain (2021)
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Abstract:
Broca’s area in the posterior half of the left inferior frontal gyrus has long been thought to be critical for speech production. The current view is that long-term speech production outcome in patients with Broca’s area damage is best explained by the combination of damage to Broca’s area and neighbouring regions including the underlying white matter, which was also damaged in Paul Broca’s two historic cases. Here, we dissociate the effect of damage to Broca’s area from the effect of damage to surrounding areas by studying long-term speech production outcome in 134 stroke survivors with relatively circumscribed left frontal lobe lesions that spared posterior speech production areas in lateral inferior parietal and superior temporal association cortices. Collectively, these patients had varying degrees of damage to one or more of nine atlas-based grey or white matter regions: Brodmann areas 44 and 45 (together known as Broca’s area), ventral premotor cortex, primary motor cortex, insula, putamen, the anterior segment of the arcuate fasciculus, uncinate fasciculus and frontal aslant tract. Spoken picture description scores from the Comprehensive Aphasia Test were used as the outcome measure. Multiple regression analyses allowed us to tease apart the contribution of other variables influencing speech production abilities such as total lesion volume and time post-stroke. We found that, in our sample of patients with left frontal damage, long-term speech production impairments (lasting beyond 3 months post-stroke) were solely predicted by the degree of damage to white matter, directly above the insula, in the vicinity of the anterior part of the arcuate fasciculus, with no contribution from the degree of damage to Broca’s area (as confirmed with Bayesian statistics). The effect of white matter damage cannot be explained by a disconnection of Broca’s area, because speech production scores were worse after damage to the anterior arcuate fasciculus with relative sparing of Broca’s area than after damage to Broca’s area with relative sparing of the anterior arcuate fasciculus. Our findings provide evidence for three novel conclusions: (i) Broca’s area damage does not contribute to long-term speech production outcome after left frontal lobe strokes; (ii) persistent speech production impairments after damage to the anterior arcuate fasciculus cannot be explained by a disconnection of Broca’s area; and (iii) the prior association between persistent speech production impairments and Broca’s area damage can be explained by co-occurring white matter damage, above the insula, in the vicinity of the anterior part of the arcuate fasciculus.
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Original Articles
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URL: https://doi.org/10.1093/brain/awaa460
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8041045/
http://www.ncbi.nlm.nih.gov/pubmed/33517378
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| 10 |
Changes in Community Clinicians’ Attitudes and Competence following a Transdiagnostic Cognitive Behavioral Therapy Training
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In: Implement Res Pract (2021)
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Brain regions that support accurate speech production after damage to Broca’s area
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In: Brain Commun (2021)
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Evaluating the Impact of Puzzle-based Learning on Creativity, Engagement and Intuition of STEM Tertiary Students
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CorCenCC: Corpws Cenedlaethol Cymraeg Cyfoes – the National Corpus of Contemporary Welsh ...
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Novel Computational Linguistic Measures, Dialogue System and the Development of SOPHIE: Standardized Online Patient for Healthcare Interaction Education ...
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Multimodal estimation and communication of latent semantic knowledge for robust execution of robot instructions
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In: Prof. Roy (2020)
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Patterns of Multidisciplinary Care of Head and Neck Squamous Cell Carcinoma in Medicare Patients
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In: JAMA Otolaryngol Head Neck Surg (2020)
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Black holes, gravitational waves and fundamental physics: a roadmap
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In: Class.Quant.Grav. ; https://hal.archives-ouvertes.fr/hal-01833690 ; Class.Quant.Grav., 2019, 36 (14), pp.143001. ⟨10.1088/1361-6382/ab0587⟩ (2019)
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Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
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In: Genetics in medicine : official journal of the American College of Medical Genetics, vol 21, iss 8 (2019)
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Black holes, gravitational waves and fundamental physics: a roadmap
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