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1
Common Genetic Variants In Foxp2 Are Not Associated With Individual Differences In Language Development ...
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2
Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ
Eicher, John D.; Powers, Natalie R.; Miller, Laura L.. - : Springer Berlin Heidelberg, 2014
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3
Language problems in children with ADHD: a community-based study
Sciberras, Emma; Mueller, Kathryn L.; Efron, Daryl. - : American Academy of Pediatrics, 2014
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4
Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
Eicher, John D.; Powers, Natalie R.; Cho, Kelly. - : Public Library of Science, 2013
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5
Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
Abstract: Language impairment (LI) and reading disability (RD) are common pediatric neurobehavioral disorders that frequently co-occur, suggesting they share etiological determinants. Recently, our group identified prenatal nicotine exposure as a factor for RD and poor reading performance. Using smoking questionnaire and language data from the Avon Longitudinal Study of Parents and Children, we first determined if this risk could be expanded to other communication disorders by evaluating whether prenatal nicotine exposure increases risk for LI and poor performance on language tasks. Prenatal nicotine exposure increased LI risk (OR = 1.60; p = 0.0305) in a dose-response fashion with low (OR = 1.25; p = 0.1202) and high (OR = 3.84; p = 0.0002) exposures. Next, hypothesizing that the effects of prenatal nicotine may also implicate genes that function in nicotine related pathways, we determined whether known nicotine dependence (ND) genes associate with performance on language tasks. We assessed the association of 33 variants previously implicated in ND with LI and language abilities, finding association between ANKK1/DRD2 and performance on language tasks (p≤0.0003). The associations of markers within ANKK1 were replicated in a separate LI case-control cohort (p<0.05). Our results show that smoking during pregnancy increases the risk for LI and poor performance on language tasks and that ANKK1/DRD2 contributes to language performance. More precisely, these findings suggest that prenatal environmental factors influence in utero development of neural circuits vital to language. Our association of ANKK1/DRD2 further implicates the role of nicotine-related pathways and dopamine signaling in language processing, particularly in comprehension and phonological memory.
Keyword: Research Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655151
https://doi.org/10.1371/journal.pone.0063762
http://www.ncbi.nlm.nih.gov/pubmed/23691092
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6
Language as shaped by the brain : [including open peer commentary and authors' response]
Enfield, N. J. (Komm.); Smith, Andrew D. M. (Komm.); Ragir, Sonia (Komm.)...
In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 31 (2008) 5, 489-558
BLLDB
OLC Linguistik
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7
Language as shaped by the brain; the brain as shaped by development
In: Behavioral and brain sciences. - New York, NY [u.a.] : Cambridge Univ. Press 31 (2008) 5, 535
OLC Linguistik
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