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Primary Progressive Aphasia: Use of Graphical Markers for an Early and Differential Diagnosis
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In: Brain Sci (2021)
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Contribution of the Cognitive Approach to Language Assessment to the Differential Diagnosis of Primary Progressive Aphasia
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In: Brain Sci (2021)
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Validation of the Dépistage Cognitif de Québec in the Oldest Old
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In: Can Geriatr J (2020)
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The Nonverbal Processing of Actions Is an Area of Relative Strength in the Semantic Variant of Primary Progressive Aphasia
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Les troubles morphologiques flexionnels dans la maladie de Parkinson : origine procédurale et/ou exécutive ?
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Production of morphologically derived words in the semantic variant of primary progressive aphasia: preserved decomposition and composition but impaired validation
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Toward an Executive Origin for Acquired Phonological Dyslexia: A Case of Specific Deficit of Context-Sensitive Grapheme-to-Phoneme Conversion Rules
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The role of Basal Ganglia in Language Production: evidence from Parkinson's disease
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A SEMantic and EPisodic Memory Test (SEMEP) Developed within the Embodied Cognition Framework: Application to Normal Aging, Alzheimer's Disease and Semantic Dementia
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In: ISSN: 1664-1078 ; Frontiers in Psychology ; https://hal.archives-ouvertes.fr/hal-02131641 ; Frontiers in Psychology, Frontiers, 2017, 8, pp.1493. ⟨10.3389/fpsyg.2017.01493⟩ (2017)
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The Role of the Left Anterior Temporal Lobe for Unpredictable and Complex Mappings in Word Reading
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The role of the left anterior temporal lobe for unpredictable and complex mappings in word reading
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Normative data for phonemic and semantic verbal fluency test in the adult French–Quebec population and validation study in Alzheimer’s disease and depression ...
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Normative data for phonemic and semantic verbal fluency test in the adult French–Quebec population and validation study in Alzheimer’s disease and depression ...
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Conception or *conceivation? The processing of derivational morphology in semantic dementia
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Recommandations consensuelles pour la description de trois variantes de l’aphasie primaire progressive : limites et controverses quant aux troubles du langage
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Regularity and beyond: Impaired production and comprehension of inflectional morphology in semantic dementia
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Naming unique entities in the semantic variant of primary progressive aphasia and Alzheimer's disease : Towards a better understanding of the semantic impairment
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Articulatory Changes in Vowel Production following STN DBS and Levodopa Intake in Parkinson's Disease
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Abstract:
Purpose. To investigate the impact of deep brain stimulation of the subthalamic nucleus (STN DBS) and levodopa intake on vowel articulation in dysarthric speakers with Parkinson's disease (PD). Methods. Vowel articulation was assessed in seven Quebec French speakers diagnosed with idiopathic PD who underwent STN DBS. Assessments were conducted on- and off-medication, first prior to surgery and then 1 year later. All recordings were made on-stimulation. Vowel articulation was measured using acoustic vowel space and formant centralization ratio. Results. Compared to the period before surgery, vowel articulation was reduced after surgery when patients were off-medication, while it was better on-medication. The impact of levodopa intake on vowel articulation changed with STN DBS: before surgery, levodopa impaired articulation, while it no longer had a negative effect after surgery. Conclusions. These results indicate that while STN DBS could lead to a direct deterioration in articulation, it may indirectly improve it by reducing the levodopa dose required to manage motor symptoms. These findings suggest that, with respect to speech production, STN DBS and levodopa intake cannot be investigated separately because the two are intrinsically linked. Along with motor symptoms, speech production should be considered when optimizing therapeutic management of patients with PD.
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Keyword:
Clinical Study
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617696/ https://doi.org/10.1155/2015/382320 http://www.ncbi.nlm.nih.gov/pubmed/26558134
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