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A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study
In: Research outputs 2014 to 2021 (2020)
Abstract: Background Effectiveness of early intensive aphasia rehabilitation after stroke is unknown. The Very Early Rehabilitation for SpEech trial (VERSE) aimed to determine whether intensive aphasia therapy, beginning within 14 days after stroke, improved communication recovery compared to usual care. Methods Prospective, randomized, single-blinded trial conducted at 17 acute-care hospitals across Australia/New Zealand from 2014 to 2018. Participants with aphasia following acute stroke were randomized to receive usual care (direct usual care aphasia therapy), or one of two higher intensity regimens (20 sessions of either non-prescribed (usual care-plus or prescribed (VERSE) direct aphasia therapy). The primary outcome was improvement of communication on the Western Aphasia Battery-Revised Aphasia Quotient (AQ) at 12 weeks after stroke. Our pre-planned intention to treat analysis combined high intensity groups for the primary outcome. Findings Among 13,654 acute stroke patients screened, 25% (3477) had aphasia, of whom 25% (866) were eligible and 246 randomized to usual care (n = 81; 33%), usual care-plus (n = 82; 33%) or VERSE (n = 83; 34%). At 12 weeks after stroke, the primary outcome was assessed in 217 participants (88%); 14 had died, 9 had withdrawn, and 6 were too unwell for assessment. Communication recovery was 50.3% (95% CI 45.7–54.8) in the high intensity group (n = 147) and 52.1% (95% CI 46.1–58.1) in the usual care group (n = 70; difference −1.8, 95% CI −8.7–5.0). There was no difference between groups in non-fatal or fatal adverse events (p = 0.72). Interpretation Early, intensive aphasia therapy did not improve communication recovery within 12 weeks post stroke compared to usual care.
Keyword: Aphasia; communication; early; Medicine and Health Sciences; rehabilitation; speech; stroke; therapy fidelity
URL: https://ro.ecu.edu.au/ecuworkspost2013/8876
https://ro.ecu.edu.au/cgi/viewcontent.cgi?article=9882&context=ecuworkspost2013
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2
sj-pdf-1-wso-10.1177_1747493020961926 - Supplemental material for A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study ...
Godecke, Erin; Armstrong, Elizabeth; Rai, Tapan. - : SAGE Journals, 2020
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3
sj-pdf-1-wso-10.1177_1747493020961926 - Supplemental material for A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study ...
Godecke, Erin; Armstrong, Elizabeth; Rai, Tapan. - : SAGE Journals, 2020
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4
A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study ...
Godecke, Erin; Armstrong, Elizabeth; Rai, Tapan. - : SAGE Journals, 2020
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5
sj-pdf-1-wso-10.1177_1747493020961926 - Supplemental material for A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study ...
Godecke, Erin; Armstrong, Elizabeth; Rai, Tapan. - : SAGE Journals, 2020
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6
A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study ...
Godecke, Erin; Armstrong, Elizabeth; Rai, Tapan. - : SAGE Journals, 2020
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7
A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study ...
Godecke, Erin; Armstrong, Elizabeth; Rai, Tapan. - : SAGE Journals, 2020
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8
A randomized control trial of intensive aphasia therapy after acute stroke: The Very Early Rehabilitation for SpEech (VERSE) study
In: Int J Stroke (2020)
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9
Constraint-induced or multi-modal personalized aphasia rehabilitation (COMPARE): A randomized controlled trial for stroke-related chronic aphasia
In: Research outputs 2014 to 2021 (2019)
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10
Constraint-induced or multi-modal personalized aphasia rehabilitation (COMPARE): a randomized controlled trial for stroke-related chronic aphasia
Rose, Miranda L.; Copland, David; Nickels, Lyndsey. - : Sage Publications, 2019
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11
Treatment for people with chronic aphasia - investigation of high and low intensity, constraint and multimodal treatments
Pierce, John E.; Foster, Abby; Hurley, Melanie. - : Sage Publications, 2017
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12
Constraint-induced aphasia therapy (CIAT): a randomised controlled trial in very early stroke rehabilitation
In: Research outputs 2014 to 2021 (2016)
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13
A randomized controlled trial of very early rehabilitation in speech after stroke
In: Research outputs 2014 to 2021 (2016)
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14
A comparison of aphasia therapy outcomes before and after a Very Early Rehabilitation programme following stroke
In: International journal of language & communication disorders. - Oxford : Wiley-Blackwell 49 (2014) 2, 149-161
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15
A comparison of aphasia therapy outcomes before and after a Very Early Rehabilitation programme following stroke
In: Research outputs 2014 to 2021 (2014)
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16
Amount of therapy matters in very early aphasia rehabilitation after stroke: A clinical prognostic model
In: Research outputs 2013 (2013)
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17
Very early poststroke aphasia therapy: A pilot randomized controlled efficacy trial
In: Research outputs 2011 (2011)
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18
Very early poststroke aphasia therapy: A pilot randomized controlled efficacy trial
In: Medical Papers and Journal Articles (2011)
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