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1
Connected speech markers of amyloid burden in primary progressive aphasia
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2
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Chapleau, Marianne; Bedetti, Christophe; Devenyi, Gabriel A. - : eScholarship, University of California, 2020
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3
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease.
Abstract: BackgroundIncreasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. The goal of the present study is to conduct a detailed characterization of the impact of svPPA on global hippocampus volume and morphology compared with control subjects and patients with Alzheimer's disease (AD).MethodsWe measured hippocampal volume and deformation-based shape differences in 22 patients with svPPA compared with 99 patients with AD and 92 controls. Multiple Automatically Generated Templates Brain Segmentation Algorithm (MAGeT-Brain) was used on MRI images obtained at the diagnostic visit.ResultsComparable left and right hippocampal atrophy were observed in svPPA and AD. Deformation-based shape analysis showed a common pattern of morphological deformation in svPPA and AD compared with controls. More specifically, both svPPA and AD showed inward deformations in the dorsal surface of the hippocampus, from head to tail on the left side, and more limited to the anterior portion of the body in the right hemisphere. These results also pointed out that both diseases are characterized by a lateral displacement of the central part (body) of the hippocampus.DiscussionOur study provides critical new evidence of hippocampal morphological changes in svPPA, similar to those found in AD. These findings highlight the importance of considering morphological hippocampal changes as part of the anatomical profile of patients with svPPA.
Keyword: 2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Adult; Aged; Aging; Alzheimer Disease; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Atrophy; Automated segmentation; Biomedical Imaging; Brain; Brain Disorders; Clinical Research; Deformation-based shape analysis; Dementia; Female; Hippocampus; Humans; MAGeT brain; Magnetic Resonance Imaging; Male; Middle Aged; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Semantic variant of primary progressive aphasia; Semantics
URL: https://escholarship.org/uc/item/9c4370k3
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4
Predicting Early Post-stroke Aphasia Outcome From Initial Aphasia Severity
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5
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer’s disease
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6
Predicting early post-stroke aphasia outcome from initial aphasia severity
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7
Norms of conceptual familiarity for 3,596 French nouns and their contribution in lexical decision
In: ISSN: 1554-351X ; EISSN: 1554-3528 ; Behavior Research Methods ; https://hal.archives-ouvertes.fr/hal-03378911 ; Behavior Research Methods, Psychonomic Society, Inc, 2019, 51 (5), pp.2238-2247. ⟨10.3758/s13428-018-1106-8⟩ (2019)
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8
Test-Retest Reliability of Diffusion Measures Extracted Along White Matter Language Fiber Bundles Using HARDI-Based Tractography
Boukadi, Mariem; Marcotte, Karine; Bedetti, Christophe. - : Frontiers Media S.A., 2019
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9
Visual and auditory perceptual strength norms for 3,596 French nouns and their relationship with other psycholinguistic variables
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10
The role of the hippocampus in the semantic variant of primary progressive aphasia : a resting‐state fcMRI study
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11
Test-retest reliability of diffusion measures extracted along white matter language fiber bundles using HARDI-based tractography
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12
Norms of conceptual familiarity for 3,596 French nouns and their contribution in lexical decision
In: ISSN: 1554-351X ; EISSN: 1554-3528 ; Behavior Research Methods ; https://hal.archives-ouvertes.fr/hal-01869633 ; Behavior Research Methods, Psychonomic Society, Inc, 2018, ⟨10.3758/s13428-018-1106-8⟩ (2018)
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13
Norms of concept familiarity and emotional valence for 3,596 French nouns and their contribution in lexical decision
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