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21
Abnormal Subcortical Components of the Corticostriatal System in Young Adults with DLI: A Combined Structural MRI and DTI Study
BASE
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22
Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
Eicher, John D.; Powers, Natalie R.; Cho, Kelly. - : Public Library of Science, 2013
BASE
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23
Growing Up With a Cochlear Implant: Education, Vocation, and Affiliation
In: Journal of deaf studies and deaf education. - Cary, NC : Oxford Univ. Press 17 (2012) 4, 483
OLC Linguistik
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24
Reinforcement learning in young adults with developmental language impairment
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 123 (2012) 3, 154-163
BLLDB
OLC Linguistik
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25
Exploring the comorbidity of attention-deficit, hyperactivity disorder and language, speech, and reading disorders
Tomblin, J. Bruce (Hrsg.). - Hagerstown, Md. : Lippincott Williams & Wilkins, 2012
UB Frankfurt Linguistik
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26
The Aromatase Gene CYP19A1: Several Genetic and Functional Lines of Evidence Supporting a Role in Reading, Speech and Language
Abstract: Inspired by the localization, on 15q21.2 of the CYP19A1 gene in the linkage region of speech and language disorders, and a rare translocation in a dyslexic individual that was brought to our attention, we conducted a series of studies on the properties of CYP19A1 as a candidate gene for dyslexia and related conditions. The aromatase enzyme is a member of the cytochrome P450 super family, and it serves several key functions: it catalyzes the conversion of androgens into estrogens; during early mammalian development it controls the differentiation of specific brain areas (e.g. local estrogen synthesis in the hippocampus regulates synaptic plasticity and axonal growth); it is involved in sexual differentiation of the brain; and in songbirds and teleost fishes, it regulates vocalization. Our results suggest that variations in CYP19A1 are associated with dyslexia as a categorical trait and with quantitative measures of language and speech, such as reading, vocabulary, phonological processing and oral motor skills. Variations near the vicinity of its brain promoter region altered transcription factor binding, suggesting a regulatory role in CYP19A1 expression. CYP19A1 expression in human brain correlated with the expression of dyslexia susceptibility genes such as DYX1C1 and ROBO1. Aromatase-deficient mice displayed increased cortical neuronal density and occasional cortical heterotopias, also observed in Robo1−/− mice and human dyslexic brains, respectively. An aromatase inhibitor reduced dendritic growth in cultured rat neurons. From this broad set of evidence, we propose CYP19A1 as a candidate gene for human cognitive functions implicated in reading, speech and language.
Keyword: Original Research
URL: https://doi.org/10.1007/s10519-012-9532-3
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375077
http://www.ncbi.nlm.nih.gov/pubmed/22426781
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27
Grammar Predicts Procedural Learning and Consolidation Deficits in Children with Specific Language Impairment
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28
Electrophysiological correlates of rapid auditory and linguistic processing in adolescents with specific language impairment
In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 115 (2010) 3, 162-181
BLLDB
OLC Linguistik
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29
Sequential expectations: the role of prediction-based learning in language
In: Topics in cognitive science. - Hoboken, NJ [u.a.] : Wiley 2 (2010) 1, 138-153
BLLDB
OLC Linguistik
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30
Sequential Expectations: The Role of Prediction-Based Learning in Language
In: Topics in cognitive science. - Hoboken, NJ [u.a.] : Wiley 2 (2010) 1, 138-153
OLC Linguistik
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31
Individual differences in online spoken word recognition: Implications for SLI
BASE
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32
On-Line Individual Differences in Statistical Learning Predict Language Processing
Misyak, Jennifer B.; Christiansen, Morten H.; Tomblin, J. Bruce. - : Frontiers Research Foundation, 2010
BASE
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33
Electrophysiological Correlates of Rapid Auditory and Linguistic Processing in Adolescents with Specific Language Impairment
BASE
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34
Sequential expectations : the role of prediction-based learning in language
Misyak, Jennifer B.; Christiansen, Morten H.; Tomblin, J. Bruce. - : Wiley-Blackwell Publishing, Inc., 2010
BASE
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35
Language Features in a mother and daughter of a chromosome 7;13 translocation involving FOXP2
In: Journal of speech, language, and hearing research. - Rockville, Md. : American Speech-Language-Hearing Association 52 (2009) 5, 1157-1174
BLLDB
OLC Linguistik
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36
The handbook of child language disorders
Edwards, Jan; Fletcher, Paul; Hook, Pamela E.. - New York : Psychology Press, 2009
BLLDB
UB Frankfurt Linguistik
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37
Childern with specific language impairment
In: The Cambridge handbook of child language (Cambridge, 2009), p. 417-432
MPI für Psycholinguistik
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38
Children with specific language impairment
In: The Cambridge handbook of child language. - Cambridge [u.a.] : Cambridge Univ. Press (2009), 417-431
BLLDB
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39
Seeing the world through a third eye: developmental systems theory looks beyond the nativist-empiricist debate : [authors' response]
In: Child development perspectives. - Hoboken, NJ : Wiley 3 (2009) 2, 103-105
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40
Short arms and talking eggs: why we should no longer abide the nativist-empiricist debate : [main article]
In: Child development perspectives. - Hoboken, NJ : Wiley 3 (2009) 2, 79-87
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