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Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
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In: Nature communications, vol 13, iss 1 (2022)
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Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context. ...
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Balancing Prediction and Sensory Input in Speech Comprehension: The Spatiotemporal Dynamics of Word Recognition in Context.
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Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.
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In: Autism research : official journal of the International Society for Autism Research, vol 11, iss 4 (2018)
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Thin-film micro-electrode stimulation of the cochlea in rats exposed to aminoglycoside induced hearing loss
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In: Australian Institute for Innovative Materials - Papers (2016)
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Parole d'introduzione
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In: Zeitschrift für romanische Philologie, vol. 132, no. 4 (2016)
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Estudo da carcinogênese bucal experimental utilizando-se o óxido de nitroquinolina (4-NQO) em ratos
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Ação do curcumin sobre os períodos iniciais da carcinogênese bucal induzida por 4-NQO em modelo murino
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A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation.
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In: PloS one, vol 9, iss 7 (2014)
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Apc-Mutant Kyoto Apc Delta (KAD) Rats Are Susceptible to 4-NQO-Induced Tongue Carcinogenesis
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In: Cancers ; Volume 6 ; Issue 3 ; Pages 1522-1539 (2014)
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Abstract:
Despite widening interest in the possible association between infection/ inflammation and cancer development, knowledge of this issue in relation to oral cancer remains inadequate. This study aimed to determine the susceptibility of Apc-mutant Kyoto Apc Delta (KAD) rats, which are vulnerable to developing inflammation-associated colorectal carcinogenesis, to 4-nitroquinoline 1-oxide (4-NQO)-induced tongue carcinogenesis in order to clarify the role of inflammation in oral cancer. KAD (20 males and 22 females) and F344/NS1c (22 males and 23 females) rats received drinking water with or without 4-NQO (20 ppm) for eight weeks. Histopathological and immunohistochemical analyses of the tongue were performed at week 20. Additionally, the mRNA expression of inflammatory cytokines in the tongue mucosa was determined at week 8. Tongue squamous cell carcinoma (SCC) developed in the KAD and F344/NS1c rats that received 4-NQO. Regardless of gender, the incidence and multiplicity of tongue SCC were greater in the KAD rats than in the F344/NS1c rats. In addition, the multiplicity of tongue SCC in the female KAD rats was significantly greater than that observed in the male KAD (p < ; 0.01) and female F344/NS1c rats (p < ; 0.05). The levels of inflammation and the mRNA expression of inflammatory cytokines in the tongue in the 4-NQO-treated female KAD rats were the highest among the rats given 4-NQO. These results show that KAD rats, particularly females, are susceptible to 4-NQO-induced tongue carcinogenesis, suggesting the utility of models employing KAD rats for investigating the pathobiology of oral (tongue) carcinogenesis associated with inflammation.
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Keyword:
Apc mutant rats; carcinogenesis; inflammation; susceptibility; tongue
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URL: https://doi.org/10.3390/cancers6031522
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| 12 |
Un fals aparegut en el «Tirant lo Blanch»
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In: Caplletra. Revista Internacional de Filologia; Núm. 44 (2008); 55-78 (2014)
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Similarity of cortical activity patterns predicts generalization behavior.
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In: PloS one, vol 8, iss 10 (2013)
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| 14 |
Интонация как средство формальной дифференциации лексико-семантических вариантов многозначного слова в русском языке
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Москвичева, Светлана. - : Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Российский университет дружбы народов», 2011
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| 15 |
AGILE: Autonomous Global Integrated Language Exploitation
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In: DTIC (2009)
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Conceptual representations in goal-directed decision making.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2008)
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Neuropharmacological modulation of cognitive deficits after brain damage
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In: CURR OPIN NEUROL , 18 (6) 675 - 680. (2005) (2005)
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Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias.
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In: The European journal of neuroscience, vol 18, iss 6 (2003)
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Speech perception in rats: Use of duration and rise time cues in labeling of affricate/fricative sounds
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In: J EXP ANAL BEHAV , 80 (2) pp. 205-215. (2003) (2003)
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