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Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss
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Abstract:
In childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal processing. However, early therapeutic interventions targeting temporal processing may improve later speech-related outcomes. Gap detection is a measure of auditory temporal resolution that relies on the auditory cortex (ACx), and early auditory deprivation alters intrinsic and synaptic properties in the ACx. Thus, early deprivation should induce deficits in gap detection, which should be reflected in ACx gap sensitivity. We tested whether earplugging-induced, early transient auditory deprivation in male and female Mongolian gerbils caused correlated deficits in behavioral and cortical gap detection, and whether these could be rescued by a novel therapeutic approach: brief exposure to gaps in background noise. Two weeks after earplug removal, animals that had been earplugged from hearing onset throughout auditory critical periods displayed impaired behavioral gap detection thresholds (GDTs), but this deficit was fully reversed by three 1 h sessions of exposure to gaps in noise. In parallel, after earplugging, cortical GDTs increased because fewer cells were sensitive to short gaps, and gap exposure normalized this pattern. Furthermore, in deprived animals, both first-spike latency and first-spike latency jitter increased, while spontaneous and evoked firing rates decreased, suggesting that deprivation causes a wider range of perceptual problems than measured here. These cortical changes all returned to control levels after gap exposure. Thus, brief stimulus exposure, perhaps in a salient context such as the unfamiliar placement into a testing apparatus, rescued impaired gap detection and may have potential as a remediation tool for general auditory processing deficits.
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Keyword:
Research Articles
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URL: https://doi.org/10.1523/JNEUROSCI.0916-17.2017
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551066/
http://www.ncbi.nlm.nih.gov/pubmed/28706081
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| 2 |
Multi-domain joint semantic frame parsing using bi-directional RNN-LSTM,” in INTERSPEECH
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In: https://www.microsoft.com/en-us/research/wp-content/uploads/2016/06/IS16_MultiJoint.pdf (2016)
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EVALUATION OF THE SIGNAL-TO-NOISE RATIO REQUIRED TO ACHIEVE THE SAME PERFORMANCE IN ENGLISH AND MANDARIN CHINESE
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Semi-supervised learning of semantic classes for query . . .
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In: http://research.microsoft.com/pubs/101154/fp0894-wang-webpost.pdf (2009)
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Acero: A discriminative training framework using N-best speech recognition transcriptions and scores for spoken utterance classification
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In: http://www1.icsi.berkeley.edu/~sibel/ICASSP2007SUC.pdf (2007)
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SGStudio: Rapid Semantic Grammar Development for Spoken Language Understanding
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In: http://research.microsoft.com/pubs/60452/2005-wang-acero-eurospeech.pdf (2005)
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| 9 |
Grammar Inference and Statistical Machine Translation
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In: http://www.is.cs.cmu.edu/papers/speech/phd-thesis/thesis-yyw.ps.gz (1998)
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| 10 |
Decoding Algorithm in Statistical Machine Translation
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In: http://www.ri.cmu.edu/pub_files/pub1/wang_ye_yi_1997_1/wang_ye_yi_1997_1.ps.gz (1997)
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| 12 |
Word Clustering With Parallel Spoken Language Corpora
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In: http://research.microsoft.com/users/yeyiwang/publications/icslp96.ps (1996)
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| 13 |
Word Clustering With Parallel Spoken Language Corpora
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In: http://www.ubka.uni-karlsruhe.de/vvv/1996/informatik/66/66.ps.gz (1996)
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| 14 |
Word clustering with parallel spoken language corpora
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In: http://www.ri.cmu.edu/pub_files/pub1/wang_ye_yi_1996_1/wang_ye_yi_1996_1.pdf (1996)
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| 15 |
Word clustering with parallel spoken language corpora
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In: http://research.microsoft.com/pubs/75238/1996-yeyiwang-icslp.pdf (1996)
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| 16 |
Word Clustering With Parallel Spoken Language Corpora
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In: http://www.asel.udel.edu/icslp/cdrom/vol4/687/a687.pdf (1996)
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| 17 |
Improved Language Modeling By Unsupervised Acquisition Of Structure
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In: ftp://ftp.cs.cmu.edu/afs/cs/project/cmt-38/ries/ftp/ries_buo_wang_icassp95.ps.gz (1995)
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| 18 |
Improved Language Modeling By Unsupervised Acquisition Of Structure
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In: http://werner.ira.uka.de/papers/speech/1995/ICASSP_95_klaus_ries.ps.gz (1995)
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| 19 |
Connectionist Transfer in Machine Translation
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In: http://research.microsoft.com/users/yeyiwang/publications/ranlp95.ps (1995)
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| 20 |
Dual-coding theory and connectionist lexical selection
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In: http://arxiv.org/pdf/cmp-lg/9405035v1.pdf (1994)
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