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Research on Modeling and Analysis of Generative Conversational System Based on Optimal Joint Structural and Linguistic Model
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Sentence comprehension in patients with dementia of the Alzheimer’s type
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Age differences in the effect of animacy on Mandarin sentence processing
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Genetic Activation of ERK5 MAP Kinase Enhances Adult Neurogenesis and Extends Hippocampus-Dependent Long-Term Memory
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Abstract:
Recent studies have shown that inhibition of adult neurogenesis impairs the formation of hippocampus-dependent memory. However, it is not known whether increasing adult neurogenesis affects the persistence of hippocampus-dependent long-term memory. Furthermore, signaling mechanisms that regulate adult neurogenesis are not fully defined. We recently reported that the conditional and targeted knock-out of ERK5 MAP kinase in adult neurogenic regions of the mouse brain attenuates adult neurogenesis in the hippocampus and disrupts several forms of hippocampus-dependent memory. Here, we developed a gain-of-function knock-in mouse model to specifically activate endogenous ERK5 in the neurogenic regions of the adult brain. We report that the selective and targeted activation of ERK5 increases adult neurogenesis in the dentate gyrus by enhancing cell survival, neuronal differentiation, and dendritic complexity. Conditional ERK5 activation also improves the performance of challenging forms of spatial learning and memory and extends hippocampus-dependent long-term memory. We conclude that enhancing signal transduction of a single signaling pathway within adult neural stem/progenitor cells is sufficient to increase adult neurogenesis and improve the persistence of hippocampus-dependent memory. Furthermore, activation of ERK5 may provide a novel therapeutic target to improve long-term memory.
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Articles
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URL: https://doi.org/10.1523/JNEUROSCI.3324-13.2014
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913867
http://www.ncbi.nlm.nih.gov/pubmed/24501354
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1 On the Mode of the Semantic Changes of Body-part Terms in English and Chinese-- Illustrated by the Examples of the Lexical Items “Hand ” and “Shou ” in the Holy Bible.
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In: http://www.lancs.ac.uk/fass/projects/corpus/UCCTS2008Proceedings/papers/Wang_and_Wang.pdf
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