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Multivariate genome-wide covariance analyses of literacy, language and working memory skills reveal distinct etiologies
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In: NPJ Sci Learn (2021)
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Polygenic scores and risk prediction for delay (Dale et al., 2020) ...
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Polygenic scores and risk prediction for delay (Dale et al., 2020) ...
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Does the Inclusion of a Genome-Wide Polygenic Score Improve Early Risk Prediction for Later Language and Literacy Delay?
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Does the Inclusion of a Genome-Wide Polygenic Score Improve Early Risk Prediction for Later Language and Literacy Delay?
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In: J Speech Lang Hear Res (2020)
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Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language
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Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language
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Assessing receptive and expressive vocabulary in child language
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In: Research methods in psycholinguistics and the neurobiology of language (Hoboken, NJ, 2018), p. 40-67
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MPI für Psycholinguistik
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Grammar Clinical Marker Yields Substantial Heritability for Language Impairments in 16-Year-Old Twins
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The genetic architecture of oral language, reading fluency, and reading comprehension : A twin study from 7 to 16 years
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The Genetic Architecture of Oral Language, Reading Fluency, and Reading Comprehension: A Twin Study From 7 to 16 Years
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Language Differences at 12 Months in Infants Who Develop Autism Spectrum Disorder
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Why does parental language input style predict child language development? A twin study of gene–environment correlation
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Language impairment from 4 to 12 years : : prediction and etiology
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds
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Harlaar, Nicole; Meaburn, Emma L.; Hayiou-Thomas, Marianna E.; Davis, Oliver S. P.; Docherty, Sophia; Hanscombe, Ken B.; Haworth, Claire M. A.; Price, Thomas S.; Trzaskowski, Maciej; Dale, Philip S.; Plomin, Robert; Jankowski, Janusz. - : American Speech-Language-Hearing Association, 2014
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Abstract:
Purpose Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach. Method The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores. Results No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome ( p < 5 × 10 −8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds. Conclusions These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants.
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Keyword:
A300 - Clinical medicine
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URL: https://doi.org/10.1044/1092-4388(2013/12-0303 http://clok.uclan.ac.uk/16160/ http://clok.uclan.ac.uk/16160/1/16160_jankowski.pdf
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The high heritability of educational achievement reflects many genetically influenced traits, not just intelligence
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Genome-wide association study of receptive language ability of 12-year-olds
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Common variation near ROBO2 is associated with expressive vocabulary in infancy
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