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Providing a parent-administered outcome measure in a bilingual family of a father and a mother of two adolescents with ASD: brief report.
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In: Developmental neurorehabilitation, vol 25, iss 2 (2022)
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Hippocampal ensembles represent sequential relationships among an extended sequence of nonspatial events.
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In: Nature communications, vol 13, iss 1 (2022)
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Parental Prepuberty Overweight and Offspring Lung Function
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In: Nutrients; Volume 14; Issue 7; Pages: 1506 (2022)
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Increased connectivity among sensory and motor regions during visual and audiovisual speech perception
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In: Open Access Publications (2022)
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He Needs to be In a Learning Community – Learning Community, a Place of Respite and Brotherhood while Persisting in College
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In: Journal of College Access (2022)
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Cross-cultural adaptation into French and validation of the SCAR-Q questionnaire ; Cross-cultural adaptation into French and validation of the SCAR-Q questionnaire.
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In: ISSN: 0962-9343 ; EISSN: 1573-2649 ; Quality of Life Research ; https://hal-amu.archives-ouvertes.fr/hal-03623447 ; Quality of Life Research, Springer Verlag, 2021, 30 (4), pp.1225-1231. ⟨10.1007/s11136-020-02719-8⟩ (2021)
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White matter disconnectivity fingerprints causally linked to dissociated forms of alexia
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In: ISSN: 2399-3642 ; Communications Biology ; https://hal.umontpellier.fr/hal-03634907 ; Communications Biology, Nature Publishing Group, 2021, 4 (1), pp.1413. ⟨10.1038/s42003-021-02943-z⟩ (2021)
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Drug induced stuttering: pharmacovigilance data ; Drug induced stuttering: pharmacovigilance data.
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In: ISSN: 1474-0338 ; EISSN: 1744-764X ; Expert Opinion on Drug Safety ; https://hal.archives-ouvertes.fr/hal-03474488 ; Expert Opinion on Drug Safety, Informa Healthcare, 2021, 20 (3), pp.373-378. ⟨10.1080/14740338.2021.1867101⟩ (2021)
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| 13 |
Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome
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Douard, Elise; Zeribi, Abderrahim; Schramm, Catherine; Tamer, Petra; Loum, Mor Absa; Nowak, Sabrina; Saci, Zohra; Lord, Marie-Pier; Rodríguez-Herreros, Borja; Jean-Louis, Martineau; Moreau, Clara; Loth, Eva; Schumann, Gunter; Pausova, Zdenka; Elsabbagh, Mayada; Almasy, Laura; Glahn, David,; Bourgeron, Thomas; Labbe, Aurélie; Paus, Tomas; Mottron, Laurent; Greenwood, Celia,; Huguet, Guillaume; Jacquemont, Sébastien
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In: ISSN: 0002-953X ; EISSN: 1535-7228 ; American Journal of Psychiatry ; https://hal-pasteur.archives-ouvertes.fr/pasteur-03325371 ; American Journal of Psychiatry, American Psychiatric Publishing, 2021, 178 (1), pp.87-98. ⟨10.1176/appi.ajp.2020.19080834⟩ (2021)
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Abstract:
International audience ; Objective:Deleterious copy number variants (CNVs) are identified in up to 20% of individuals with autism. However, levels of autism risk conferred by most rare CNVs remain unknown. The authors recently developed statistical models to estimate the effect size on IQ of all CNVs, including undocumented ones. In this study, the authors extended this model to autism susceptibility.Methods:The authors identified CNVs in two autism populations (Simons Simplex Collection and MSSNG) and two unselected populations (IMAGEN and Saguenay Youth Study). Statistical models were used to test nine quantitative variables associated with genes encompassed in CNVs to explain their effects on IQ, autism susceptibility, and behavioral domains.Results:The “probability of being loss-of-function intolerant” (pLI) best explains the effect of CNVs on IQ and autism risk. Deleting 1 point of pLI decreases IQ by 2.6 points in autism and unselected populations. The effect of duplications on IQ is threefold smaller. Autism susceptibility increases when deleting or duplicating any point of pLI. This is true for individuals with high or low IQ and after removing de novo and known recurrent neuropsychiatric CNVs. When CNV effects on IQ are accounted for, autism susceptibility remains mostly unchanged for duplications but decreases for deletions. Model estimates for autism risk overlap with previously published observations. Deletions and duplications differentially affect social communication, behavior, and phonological memory, whereas both equally affect motor skills.Conclusions:Autism risk conferred by duplications is less influenced by IQ compared with deletions. The model applied in this study, trained on CNVs encompassing >4,500 genes, suggests highly polygenic properties of gene dosage with respect to autism risk and IQ loss. These models will help to interpret CNVs identified in the clinic.
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Keyword:
[SCCO.NEUR]Cognitive science/Neuroscience; Autism Spectrum Disorder; Copy Number Variants; IQ; MESH: Adolescent; MESH: Adult; MESH: Autistic Disorder; MESH: Case-Control Studies; MESH: Child; MESH: DNA Copy Number Variations; MESH: Female; MESH: Gene Deletion; MESH: Gene Duplication; MESH: Genetic Predisposition to Disease; MESH: Genome; MESH: Humans; MESH: Intelligence; MESH: Male; MESH: Risk Factors
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URL: https://doi.org/10.1176/appi.ajp.2020.19080834
https://hal-pasteur.archives-ouvertes.fr/pasteur-03325371
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| 14 |
Human cortical encoding of pitch in tonal and non-tonal languages.
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In: Nature communications, vol 12, iss 1 (2021)
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Eighteen-month-old infants represent nonlocal syntactic dependencies.
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In: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 41 (2021)
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Neural dynamics of semantic categorization in semantic variant of primary progressive aphasia.
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An ERP index of real-time error correction within a noisy-channel framework of human communication.
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STUDIES ON GENDER LINGUISTICS IN THE FIELD OF UZBEK LANGUAGE ...
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Evidence of the interplay of genetics and culture in Ethiopia. ...
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