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SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering ...
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Out-of-Scope Intent Detection with Self-Supervision and Discriminative Training ...
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Inhibitory Mechanisms in the Processing of Negations: A Neural Reuse Hypothesis
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In: J Psycholinguist Res (2021)
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An Industry Evaluation of Embedding-based Entity Alignment ...
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Measurement of $W^{\pm}$-boson and $Z$-boson production cross-sections in $pp$ collisions at $\sqrt{s}=2.76$ TeV with the ATLAS detector
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Wearable Neurophysiological Recordings in Middle-School Classroom Correlate With Students’ Academic Performance
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Relative contributions of acoustic temporal fine structure and envelope cues for lexical tone perception in noise
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The Researches on the Ideological and Political Education Models of College Students From the Perspective of Network Discourse
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In: Cross-Cultural Communication; Vol 13, No 7 (2017): Cross-Cultural Communication; 11-16 ; 1923-6700 ; 1712-8358 (2017)
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Observation of $B^0_s\to\bar{D}^0 K^0_S$ and evidence for $B^0_s\to\bar{D}^{*0} K^0_S$ decays
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A processability approach to the L2 acquisition of Chinese syntax
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A processability approach to the L2 acquisition of Chinese syntax
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Is Accessing of Words Affected by Affective Valence Only? A Discrete Emotion View on the Emotional Congruency Effect
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Understanding Zipf's law of word frequencies through sample-space collapse in sentence formation
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A processability approach to the L2 acquisition of Chinese syntax ...
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Liu, Bo. - : The Australian National University, 2015
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The Role of Temporal Envelope and Fine Structure in Mandarin Lexical Tone Perception in Auditory Neuropathy Spectrum Disorder
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3D face tracking and multi-scale, spatio-temporal analysis of linguistically significant facial expressions and head positions in ASL
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Computer-based tracking, analysis, and visualization of linguistically significant nonmanual events in American Sign Language (ASL)
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Implications of the Wnt5a/CaMKII Pathway in Retinoic Acid-Induced Myogenic Tongue Abnormalities of Developing Mice
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Abstract:
Although proper tongue development is relevant to other structures in the craniofacial region, the molecular details of muscle development in tongue remain poorly understood. Here, we report that pregnant mice treated with retinoic acid (+RA) produce embryos with tongue malformation and a cleft palate. Histological analyses revealed that at E14.5, the tongues of +RA fetuses failed to descend and flatten. Ultrastructural analysis showed that at perinatal stage E18.5, the myofilaments failed to form normal structures of sarcomeres, and arranged disorderly in the genioglossus. The proliferation and levels of myogenic determination markers (Myf5 and MyoD) and myosin in the genioglossus were profoundly reduced. Wnt5a and Camk2d expressions were down-regulated, while levels of Tbx1, Ror2, and PKCδ were up-regulated in the tongues of +RA fetuses. In mock- and Wnt5a-transfected C2C12 (Wnt5a-C2C12) cells, Wnt5a overexpression impaired proliferation, and maintained Myf5 at a relative high level after RA treatment. Furthermore, Wnt5a overexpression positively correlated with levels of Camk2d and Ror2 in C2C12 cells after RA exposure. These data support the hypothesis that the Wnt5a/CaMKII pathway is directly involved in RA-induced hypoplasia and disorder of tongue muscles.
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Keyword:
Article
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URL: http://www.ncbi.nlm.nih.gov/pubmed/25124193 https://doi.org/10.1038/srep06082 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133706
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