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{C}as{EE}: {A} Joint Learning Framework with Cascade Decoding for Overlapping Event Extraction ...
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A General Framework for Learning Prosodic-Enhanced Representation of Rap Lyrics ...
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Play responsibly? Perceptions of Warning Messages on Lottery Tickets
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In: International Conference on Gambling & Risk Taking (2019)
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L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation
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Liu, Taiming; Zhang, Meijuan; Mukosera, George T.; Borchardt, Dan; Li, Qian; Tipple, Trent E.; Ishtiaq Ahmed, Abu Shufian; Power, Gordon G.; Blood, Arlin B.. - : Elsevier, 2019
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Abstract:
L-N(G)-Nitro arginine methyl ester (L-NAME) has been widely applied for several decades in both basic and clinical research as an antagonist of nitric oxide synthase (NOS). Herein, we show that L-NAME slowly releases NO from its guanidino nitro group. Daily pretreatment of rats with L-NAME potentiated mesenteric vasodilation induced by nitrodilators such as nitroglycerin, but not by NO. Release of NO also occurred with the NOS-inactive enantiomer D-NAME, but not with L-arginine or another NOS inhibitor L-NMMA, consistent with the presence or absence of a nitro group in their structure and their nitrodilator-potentiating effects. Metabolic conversion of the nitro group to NO-related breakdown products was confirmed using isotopically-labeled L-NAME. Consistent with Fenton chemistry, transition metals and reactive oxygen species accelerated the release of NO from L-NAME. Both NO production from L-NAME and its nitrodilator-potentiating effects were augmented under inflammation. NO release by L-NAME can confound its intended NOS-inhibiting effects, possibly by contributing to a putative intracellular NO store in the vasculature.
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Keyword:
Research Paper
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565607/ https://doi.org/10.1016/j.redox.2019.101238 http://www.ncbi.nlm.nih.gov/pubmed/31200239
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A study of deep learning methods for de-identification of clinical notes in cross-institute settings
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Representation of Deep Features using Radiologist defined Semantic Features
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Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer
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Associations between radiologist-defined semantic and automatically computed radiomic features in non-small cell lung cancer
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A Novel DFNA36 Mutation in TMC1 Orthologous to the Beethoven (Bth) Mouse Associated with Autosomal Dominant Hearing Loss in a Chinese Family
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New Early Eocene Basal tapiromorph from Southern China and Its Phylogenetic Implications
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Grey and white matter changes in children with monocular amblyopia: voxel-based morphometry and diffusion tensor imaging study
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L2 Writing Development and Tertiary Grade Level
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In: http://hrmars.com/hrmars_papers/L2_Writing_Development_and_Tertiary_Grade_Level.pdf
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The Holistic Effects of Acupuncture Treatment
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In: http://downloads.hindawi.com/journals/ecam/2014/739708.pdf
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