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1
Content Word Production during Discourse in Aphasia: Deficits in Word Quantity, Not Lexical-Semantic Complexity. ...
Alyahya, Reem SW; Halai, Ajay D; Conroy, Paul. - : Apollo - University of Cambridge Repository, 2021
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2
Content Word Production during Discourse in Aphasia: Deficits in Word Quantity, Not Lexical-Semantic Complexity.
Halai, Ajay D; Alyahya, Reem SW; Conroy, Paul. - : MIT Press - Journals, 2021. : Department of Psychiatry, 2021. : J Cogn Neurosci, 2021
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3
Graded, multidimensional intra- and intergroup variations in primary progressive aphasia and post-stroke aphasia.
In: Brain : a journal of neurology, vol 143, iss 10 (2020)
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4
The verbal, non-verbal and structural bases of functional communication abilities in aphasia ...
Schumacher, Rahel; Bruehl, Stefanie; Halai, Ajay D. - : Oxford University Press, 2020
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5
Investigating the effect of changing parameters when building prediction models in post-stroke aphasia
In: Nat Hum Behav (2020)
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6
The verbal, non-verbal and structural bases of functional communication abilities in aphasia
In: Brain Commun (2020)
Abstract: The ability to communicate, functionally, after stroke or other types of acquired brain injury is crucial for the person involved and the people around them. Accordingly, assessment of functional communication is increasingly used in large-scale randomized controlled trials as the primary outcome measure. Despite the importance of functional communication abilities to everyday life and their centrality to the measured efficacy of aphasia interventions, there is little knowledge about how commonly used measures of functional communication relate to each other, whether they capture and grade the full range of patients’ remaining communication skills and how these abilities relate to the patients’ verbal and non-verbal impairments as well as the underpinning lesions. Going beyond language-only factors is essential given that non-verbal abilities can play a crucial role in an individual’s ability to communicate effectively. This study, based on a large sample of patients covering the full range and types of post-stroke aphasia, addressed these important, open questions. The investigation combined data from three established measures of functional communication with a thorough assessment of verbal and non-verbal cognition as well as structural neuroimaging. The key findings included: (i) due to floor or ceiling effects, the full range of patients’ functional communication abilities was not captured by a single assessment alone, limiting the utility of adopting individual tests as outcome measures in randomized controlled trials; (ii) phonological abilities were most strongly related to all measures of functional communication and (iii) non-verbal cognition was particularly crucial when language production was relatively impaired and other modes of communication were allowed, when patients rated their own communication abilities, and when carers rated patients’ basic communication abilities. Finally, in addition to lesion load being significantly related to all measures of functional communication, lesion analyses showed partially overlapping clusters in language regions for the functional communication tests. Moreover, mirroring the findings from the regression analyses, additional regions previously associated with non-verbal cognition emerged for the Scenario Test and for the Patient Communication Outcome after Stroke rating scale. In conclusion, our findings elucidated the cognitive and neural bases of functional communication abilities, which may inform future clinical practice regarding assessments and therapy. In particular, it is necessary to use more than one measure to capture the full range and multifaceted nature of patients’ functional communication abilities and a therapeutic focus on non-verbal cognition might have positive effects on this important aspect of activity and participation.
Keyword: Original Article
URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660039/
https://doi.org/10.1093/braincomms/fcaa118
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7
Evaluating the granularity and statistical structure of lesions and behaviour in post-stroke aphasia
In: Brain Commun (2020)
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8
A unified model of post-stroke language deficits including discourse production and their neural correlates
In: Brain (2020)
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9
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia ...
Schumacher, Rahel; Halai, Ajay D; Lambon Ralph, Matthew A. - : Oxford University Press, 2019
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10
Assessing and mapping language, attention and executive multidimensional deficits in stroke aphasia
Schumacher, Rahel; Halai, Ajay D; Lambon Ralph, Matthew A. - : Oxford University Press, 2019
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11
Unification of behavioural, computational and neural accounts of word production errors in post-stroke aphasia
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12
Noun and verb processing in aphasia: Behavioural profiles and neural correlates
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13
Relating resting-state hemodynamic changes to the variable language profiles in post-stroke aphasia
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14
Predicting the pattern and severity of chronic post-stroke language deficits from functionally-partitioned structural lesions
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15
Triangulation of language-cognitive impairments, naming errors and their neural bases post-stroke
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16
The behavioural patterns and neural correlates of concrete and abstract verb processing in aphasia: A novel verb semantic battery
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