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Tractography of supplementary motor area projections in progressive speech apraxia and aphasia
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In: Neuroimage Clin (2022)
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A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia
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In: Brain Sci (2022)
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Orofacial Muscle Strength across the Dysarthrias
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In: Brain Sci (2022)
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| 4 |
Longitudinal speech rate in progressive AOS (Utianski et al., 2021) ...
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| 5 |
Longitudinal speech rate in progressive AOS (Utianski et al., 2021) ...
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| 6 |
A Cognitive Psychometric Investigation of Word Production and Phonological Error Rates in Logopenic Progressive Aphasia
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In: Am J Speech Lang Pathol (2021)
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| 7 |
Progressive Apraxia of Speech: Delays to Diagnosis and Rates of Alternative Diagnoses
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In: J Neurol (2021)
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| 8 |
Voice Therapy According to the Rehabilitation Treatment Specification System: Expert Consensus Ingredients and Targets
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In: Am J Speech Lang Pathol (2021)
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| 9 |
A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech
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In: Nat Commun (2021)
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Communication in progressive AOS and aphasia (Utianski et al., 2020) ...
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| 11 |
Communication in progressive AOS and aphasia (Utianski et al., 2020) ...
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| 12 |
Communication Limitations in Patients With Progressive Apraxia of Speech and Aphasia
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In: Am J Speech Lang Pathol (2020)
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| 13 |
Lewy body disease is a contributor to logopenic progressive aphasia phenotype
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In: Ann Neurol (2020)
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| 14 |
Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study
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In: Eur J Neurol (2020)
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| 15 |
Dementia with Lewy bodies presenting as Logopenic Variant Primary Progressive Aphasia
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In: Neurocase (2020)
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| 16 |
Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes
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In: Neurology (2020)
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| 17 |
An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant
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Whitwell, Jennifer L.; Stevens, Chase A.; Duffy, Joseph R.; Clark, Heather M.; Machulda, Mary M.; Strand, Edythe A.; Martin, Peter R.; Utianski, Rene L.; Botha, Hugo; Spychalla, Anthony J.; Senjem, Matthew L.; Schwarz, Christopher G.; Jack, Clifford R.; Ali, Farwa; Hassan, Anhar; Josephs, Keith A.
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In: Mov Disord Clin Pract (2019)
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Abstract:
BACKGROUND: The Movement Disorder Society clinical criteria for progressive supranuclear palsy (PSP) provide a framework for assessing the presence/severity of clinical symptoms and define a speech/language variant of PSP. OBJECTIVES: To evaluate the clinical criteria in a cohort of speech/language patients with longitudinal follow‐up. METHODS: A total of 52 patients presenting with progressive apraxia of speech and/or agrammatic aphasia were followed longitudinally for up to 6 visits with clinical assessments and magnetic resonance imaging. We assessed oculomotor, postural instability, and akinesia diagnostic levels and determined whether patients met criteria for possible PSP‐speech/language or probable PSP at each visit. Kaplan‐Meier curves assessed time‐to‐event probabilities according to age. Statistical parametric mapping and midbrain volume were assessed according to disease progression. RESULTS: Few PSP symptoms were observed early in the disease, with oculomotor abnormalities and falls first observed 2 years after onset. Falls were more common than vertical supranuclear gaze palsy. Bradykinesia and rigidity commonly developed but axial was rarely greater than appendicular rigidity. During follow‐up, 54% met criteria for possible PSP‐speech/language, 38% for probable PSP‐Richardson's syndrome, and 38% for probable PSP‐parkinsonism, most commonly 6 to 6.9 years after onset. The probability of developing PSP was greater when onset was at an age older than 70 years. Patients who progressed to probable PSP had more parkinsonism and oculomotor impairment at baseline and greater midbrain atrophy when compared with those who did not develop probable PSP. CONCLUSIONS: Symptoms typical of PSP commonly develop in patients presenting with a progressive speech/language disorder. Older age appears to be an important prognostic factor in these patients.
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Keyword:
Research Articles
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URL: http://www.ncbi.nlm.nih.gov/pubmed/31392246
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660227/
https://doi.org/10.1002/mdc3.12796
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| 18 |
Western Aphasia Battery–Revised Profiles in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech
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In: Am J Speech Lang Pathol (2019)
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| 19 |
Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia
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In: Brain Lang (2019)
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| 20 |
The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia
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