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Tractography of supplementary motor area projections in progressive speech apraxia and aphasia
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In: Neuroimage Clin (2022)
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A Preliminary Report of Network Electroencephalographic Measures in Primary Progressive Apraxia of Speech and Aphasia
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In: Brain Sci (2022)
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Orofacial Muscle Strength across the Dysarthrias
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In: Brain Sci (2022)
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Longitudinal speech rate in progressive AOS (Utianski et al., 2021) ...
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Longitudinal speech rate in progressive AOS (Utianski et al., 2021) ...
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A Cognitive Psychometric Investigation of Word Production and Phonological Error Rates in Logopenic Progressive Aphasia
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In: Am J Speech Lang Pathol (2021)
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Progressive Apraxia of Speech: Delays to Diagnosis and Rates of Alternative Diagnoses
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In: J Neurol (2021)
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Voice Therapy According to the Rehabilitation Treatment Specification System: Expert Consensus Ingredients and Targets
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In: Am J Speech Lang Pathol (2021)
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A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech
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In: Nat Commun (2021)
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Communication in progressive AOS and aphasia (Utianski et al., 2020) ...
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Communication in progressive AOS and aphasia (Utianski et al., 2020) ...
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| 12 |
Communication Limitations in Patients With Progressive Apraxia of Speech and Aphasia
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In: Am J Speech Lang Pathol (2020)
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Lewy body disease is a contributor to logopenic progressive aphasia phenotype
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In: Ann Neurol (2020)
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Association of amyloid angiopathy with microbleeds in logopenic progressive aphasia: an imaging-pathology study
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In: Eur J Neurol (2020)
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| 15 |
Dementia with Lewy bodies presenting as Logopenic Variant Primary Progressive Aphasia
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In: Neurocase (2020)
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Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes
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In: Neurology (2020)
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An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant
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In: Mov Disord Clin Pract (2019)
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Western Aphasia Battery–Revised Profiles in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech
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In: Am J Speech Lang Pathol (2019)
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Clinical and Neuroimaging Characteristics of Clinically Unclassifiable Primary Progressive Aphasia
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In: Brain Lang (2019)
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The influence of β-amyloid on [(18)F]AV-1451 in semantic variant of primary progressive aphasia
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Whitwell, Jennifer L.; Martin, Peter R.; Duffy, Joseph R.; Clark, Heather M.; Machulda, Mary M.; Schwarz, Christopher G.; Weigand, Stephen D.; Sintini, Irene; Senjem, Matthew L.; Ertekin-Taner, Nilufer; Botha, Hugo; Utianski, Rene L.; Graff-Radford, Jonathan; Jones, David T.; Boeve, Bradley F.; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.; Lowe, Val J.; Josephs, Keith A.. - : Lippincott Williams & Wilkins, 2019
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Abstract:
OBJECTIVE: To compare [(18)F]AV-1451 uptake in the semantic variant of primary progressive aphasia (svPPA) to Alzheimer dementia, and determine whether increased uptake in svPPA is associated with the presence of β-amyloid (Aβ). METHODS: Thirty-one participants with svPPA underwent MRI and Pittsburgh compound B–PET scanning, and 17 of these also underwent [(18)F]AV-1451 tau-PET. A global Pittsburgh compound B standardized uptake value ratio was calculated for all participants, with a cutoff of 1.42 used to define Aβ(+) participants. We assessed region and voxel-level [(18)F]AV-1451 uptake in the whole svPPA cohort and separately in Aβ(+) and Aβ(−) svPPA groups, compared to 12 Aβ(+) participants with Alzheimer dementia and 170 cognitively normal, Aβ(−) controls. RESULTS: Of the entire cohort of participants with svPPA, 26% were Aβ(+). The Aβ(+) participants were older at scan compared to the Aβ(−) participants. svPPA showed elevated [(18)F]AV-1451 uptake in anteromedial temporal regions but the degree of uptake was lower than in Alzheimer dementia. After controlling for age, Aβ(+) status in svPPA was associated with significantly higher uptake in all anteromedial and inferior/middle lateral temporal regions, but uptake was still lower than in Alzheimer dementia. CONCLUSION: Although [(18)F]AV-1451 uptake is focally elevated in svPPA, the level of uptake is much less than what occurs in Alzheimer dementia and appears to be at least partially related to Aβ. Therefore, it is possible that some of the increased uptake of [(18)F]AV-1451 in svPPA is related to binding paired helical filament tau.
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Keyword:
Article
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URL: https://doi.org/10.1212/WNL.0000000000006913
http://www.ncbi.nlm.nih.gov/pubmed/30635491
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382367/
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