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Altered patterns of directed connectivity within the reading network of dyslexic children and their relation to reading dysfluency
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Abstract:
Reading is a complex cognitive skill subserved by a distributed network of visual and language-related regions. Disruptions of connectivity within this network have been associated with developmental dyslexia but their relation to individual differences in the severity of reading problems remains unclear. Here we investigate whether dysfunctional connectivity scales with the level of reading dysfluency by examining EEG recordings during visual word and false font processing in 9-year-old typically reading children (TR) and two groups of dyslexic children: severely dysfluent (SDD) and moderately dysfluent (MDD) dyslexics. Results indicated weaker occipital to inferior-temporal connectivity for words in both dyslexic groups relative to TRs. Furthermore, SDDs exhibited stronger connectivity from left central to right inferior-temporal and occipital sites for words relative to TRs, and for false fonts relative to both MDDs and TRs. Importantly, reading fluency was positively related with forward and negatively with backward connectivity. Our results suggest disrupted visual processing of words in both dyslexic groups, together with a compensatory recruitment of right posterior brain regions especially in the SDDs during word and false font processing. Functional connectivity in the brain’s reading network may thus depend on the level of reading dysfluency beyond group differences between dyslexic and typical readers.
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Keyword:
Original Research
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URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987659/ http://www.ncbi.nlm.nih.gov/pubmed/27919003 https://doi.org/10.1016/j.dcn.2016.11.003
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Orthographic dependency in the neural correlates of reading: evidence from audiovisual integration in English readers
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In: Brain and Mind Institute Researchers' Publications (2015)
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Orthographic depth and its impact on Universal Predictors of Reading: a cross-language investigation
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Predictors of developmental dyslexia in European orthographies with varying complexity.
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In: ISSN: 0021-9630 ; EISSN: 1469-7610 ; Journal of Child Psychology and Psychiatry ; https://hal.archives-ouvertes.fr/hal-00965034 ; Journal of Child Psychology and Psychiatry, Wiley, 2013, 54 (6), pp.686-94. ⟨10.1111/jcpp.12029⟩ (2013)
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
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In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/ejhg.2013.199⟩ (2013)
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Charting the functional relevance of Broca’s area for visual word recognition and picture naming in Dutch using fMRI-guided TMS
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Support Systems for Poor Readers: Empirical Data From Six EU Member States
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In: ISSN: 0022-2194 ; Journal of Learning Disabilities ; https://hal.archives-ouvertes.fr/hal-01440410 ; Journal of Learning Disabilities, SAGE Publications, 2011, 44 (3), pp.228-245. ⟨10.1177/0022219410374235⟩ (2011)
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Cognitive Development of Fluent Word Reading Does Not Qualitatively Differ Between Transparent and Opaque Orthographies
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In: ISSN: 0022-0663 ; Journal of Educational Psychology ; https://hal.archives-ouvertes.fr/hal-01440459 ; Journal of Educational Psychology, American Psychological Association, 2010, 102 (4), pp.827-842. ⟨10.1037/a0019465⟩ (2010)
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Exploring the Role of Low Level Visual Processing in Letter–Speech Sound Integration: A Visual MMN Study
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Deviant processing of letters and speech sounds as proximate cause of reading failure: a functional magnetic resonance imaging study of dyslexic children
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Deviant processing of letters and speech sounds as proximate cause of reading failure: a functional magnetic resonance imaging study of dyslexic children
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