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Investigating the effects of handedness on the consistency of lateralization for speech production and semantic processing tasks using functional transcranial Doppler sonography
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Testing the unitary theory of language lateralization using functional transcranial Doppler sonography in adults
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CATALISE : a multinational and multidisciplinary Delphi consensus study. Identifying language impairments in children
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CATALISE : a multinational and multidisciplinary Delphi consensus study. Identifying language impairments in children
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia
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CNTNAP2 variants affect early language development in the general population
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Overlaps between autism and language impairment: phenomimicry or shared etiology?
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Lower-frequency event-related desynchronization: a signature of late mismatch responses to sounds, which is reduced or absent in children with specific language impairment
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Abstract:
Poor discrimination of non-linguistic sounds has been implicated in language-learning problems in children, but research evidence has been inconsistent. This study included 32 participants with specific language impairment (SLI) and 32 typically-developing controls aged 7 to 16 years. Frequency discrimination thresholds were estimated in a task where participants had to distinguish a higher-frequency tone from a 1000 Hz tone. Neurophysiological responses were assessed in an oddball paradigm. Stimuli were either (a) 1030- or 1200-Hz pure tones (deviants) presented in a series of standard 1000-Hz tones, or (b) syllables: deviant [da] or [bi] in a series of standard [ba]. On the behavioural task, children (7 to 11-year-olds) had high thresholds, regardless of language status, but teenagers (12-16 yr) with SLI had higher thresholds than their controls. Conventional analysis of electrophysiological responses showed no difference between groups for the mismatch negativity (MMN), but the late discriminative negativity (LDN) was reduced in amplitude for smaller deviants in participants with SLI. Time-frequency analysis revealed that whereas the MMN reflected enhanced inter-trial coherence in the theta frequency band, the LDN corresponded to a period of event-related desynchronization extending across a wide low-frequency band including delta, theta and alpha. This manifested as a drop in power in those frequencies, which was marked in the controls but reduced or absent in children with SLI across all stimulus types. This provides compelling evidence for a low-level auditory perceptual impairment in SLI that affects a processing stage after initial detection of a sound change.
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Keyword:
Article
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URL: https://doi.org/10.1523/JNEUROSCI.2217-10.2010 http://www.ncbi.nlm.nih.gov/pubmed/21084613 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044874
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Genes, cognition, and communication: insights from neurodevelopmental disorders
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Weak hand preference in children with down syndrome is associated with language deficits
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Weak hand preference in children with Down syndrome is associated with language deficits
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Heritability of specific language impairment depends on diagnostic criteria
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Heritable risk factors associated with language impairments
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Is poor frequency modulation detection linked to literacy problems? A comparison of specific reading disability and mild to moderate sensorineural hearing loss
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Speech and non-speech processing in people with specific language impairment: a behavioural and electrophysiological study
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Frequency discrimination deficits in people with specific language impairment : reliability, validity, and linguistic correlates
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