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High-resolution iris and retinal imaging in multisystemic smooth muscle dysfunction syndrome due to a novel Asn117Lys substitution in ACTA2: a case report ...
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High-resolution iris and retinal imaging in multisystemic smooth muscle dysfunction syndrome due to a novel Asn117Lys substitution in ACTA2: a case report ...
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3
High-resolution iris and retinal imaging in multisystemic smooth muscle dysfunction syndrome due to a novel Asn117Lys substitution in ACTA2: a case report
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4
Decision-making within missing person search [<Journal>]
Harrington, Kyle [Verfasser]; Brown, Michael [Sonstige]; Pinchin, James [Sonstige].
DNB Subject Category Language
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5
Inga Rimakkuna: Indigenous Frontiers in the Pastaza Basin, Peru
Homan, Joshua. - : University of Kansas, 2018
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6
The reality of the homeland security enterprise Information Sharing Environment
Brown, Michael E.. - : Monterey, California: Naval Postgraduate School, 2017
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7
Autism and Visual Impairment: a Review of the Literature
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8
Using Parallel Corpora For Language Learning ...
Brown, Michael H.. - : Zenodo, 2017
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9
Using Parallel Corpora For Language Learning ...
Brown, Michael H.. - : Zenodo, 2017
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10
Nonhuman Animals And The Relative Pronoun 'Who' In English Learner'S Dictionaries And Graded Readers ...
Brown, Michael H.. - : Zenodo, 2017
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11
Nonhuman Animals And The Relative Pronoun 'Who' In English Learner'S Dictionaries And Graded Readers ...
Brown, Michael H.. - : Zenodo, 2017
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12
Using The Sentence Corpus Of Remedial English To Introduce Data-Driven Learning Tasks ...
Brown, Michael H.. - : Zenodo, 2017
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13
Using The Sentence Corpus Of Remedial English To Introduce Data-Driven Learning Tasks ...
Brown, Michael H.. - : Zenodo, 2017
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14
'Theaw Kon Ekspect No Mooar Eawt ov a Pig thin a Grunt' : Searching for the Radical Dialect Voice in Industrial Lancashire and the West Riding, 1798–1819
Navickas, Katrina. - : Pickering and Chatto, 2012
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15
The Effect of Cultural Competence on Special Education Referral
Reyes, Shomara Yolanda. - : East Carolina University, 2010
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16
Fighting words : language policy and ethnic relations in Asia
Callahan, Mary P. (Mitarb.); Brown, Michael E. (Hrsg.); DeVotta, Neil (Mitarb.). - Cambridge, Mass. [u.a.] : MIT Press, 2003
BLLDB
UB Frankfurt Linguistik
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17
Fighting words : language policy and ethnic relations in Asia
Brown, Michael E. (Hrsg.); Ganguly, Sumit (Hrsg.). - Cambridge, Mass. [u.a.] : The MIT Press, 2003
UB Frankfurt Linguistik
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18
Diagnosing written language disabilities using the Woodcock-Johnson Tests of Educational Achievement-Revised and the Wechsler Individual Achievement Test
In: Psychological reports. - Los Angeles [u.a.] : SAGE 87 (2000) 1, 197-204
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19
Leaky Scanning Is the Predominant Mechanism for Translation of Human Papillomavirus Type 16 E7 Oncoprotein from E6/E7 Bicistronic mRNA
Abstract: Human papillomaviruses (HPV) are unique in that they generate mRNAs that apparently can express multiple proteins from tandemly arranged open reading frames. The mechanisms by which this is achieved are uncertain and are at odds with the basic predictions of the scanning model for translation initiation. We investigated the unorthodox mechanism by which the E6 and E7 oncoproteins from human papillomavirus type 16 (HPV-16) can be translated from a single, bicistronic mRNA. The short E6 5′ untranslated region (UTR) was shown to promote translation as efficiently as a UTR from Xenopus β-globin. Insertion of a secondary structural element into the UTR inhibited both E6 and E7 expression, suggesting that E7 expression depends on ribosomal scanning from the 5′ end of the mRNA. E7 translation was found to be cap dependent, but E6 was more dependent on capping and eIF4F activity than E7. Insertion of secondary structural elements at various points in the region upstream of E7 profoundly inhibited translation, indicating that scanning was probably continuous. Insertion of the E6 region between Renilla and firefly luciferase genes revealed little or no internal ribosomal entry site activity. However when E6 was located at the 5′ end of the mRNA, it permitted over 100-fold-higher levels of downstream cistron translation than did the Renilla open reading frame. Internal AUGs in the E6 region with strong or intermediate Kozak sequence contexts were unable to inhibit E7 translation, but initiation at the E7 AUG was efficient and accurate. These data support a model in which E7 translation is facilitated by an extreme degree of leaky scanning, requiring the negotiation of 13 upstream AUGs. Ribosomal initiation complexes which fail to initiate at the E6 start codon can scan through to the E7 AUG without initiating translation, but competence to initiate is achieved once the E7 AUG is reached. These findings suggest that the E6 region of HPV-16 comprises features that sponsor both translation of the E6 protein and enhancement of translation at a downstream site.
Keyword: Replication
URL: http://www.ncbi.nlm.nih.gov/pubmed/10906182
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC112249
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20
Language modeling using stochastic automata with variable length contexts
In: Computer speech and language. - Amsterdam [u.a.] : Elsevier 11 (1997) 1, 1-16
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