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Interaction between orthographic and graphomotor constraints in learning to write
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In: ISSN: 0959-4752 ; Learning and Instruction ; https://hal.archives-ouvertes.fr/hal-03620980 ; Learning and Instruction, Elsevier, 2022, 80 (101622), pp.10.1016/j.learninstruc.2022.101622. ⟨10.1016/j.learninstruc.2022.101622⟩ (2022)
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Cortical microstructure in primary progressive aphasia: a multicenter study.
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Illán-Gala, Ignacio; Montal, Victor; Borrego-Écija, Sergi; Mandelli, Maria Luisa; Falgàs, Neus; Welch, Ariane E; Pegueroles, Jordi; Santos-Santos, Miguel; Bejanin, Alexandre; Alcolea, Daniel; Dols-Icardo, Oriol; Belbin, Olivia; Sánchez-Saudinós, Mª Belén; Bargalló, Nuria; González-Ortiz, Sofía; Lladó, Albert; Blesa, Rafael; Dickerson, Bradford C; Rosen, Howard J; Miller, Bruce L; Lleó, Alberto; Gorno-Tempini, Maria Luisa; Sánchez-Valle, Raquel; Fortea, Juan
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In: Alzheimer's research & therapy, vol 14, iss 1 (2022)
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Abstract:
BackgroundCortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA).MethodsIn this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach.ResultsThe comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity.ConclusionsCortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA.
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Keyword:
2.1 Biological and endogenous factors; Acquired Cognitive Impairment; Aging; Alzheimer's disease; Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD); Alzheimer’s disease; Aphasia; Biomedical Imaging; Brain Disorders; Case-Control Studies; Clinical Research; Dementia; Diffusion; Diffusion Magnetic Resonance Imaging; Frontotemporal Dementia (FTD); Frontotemporal lobar degeneration; Humans; Magnetic resonance; Magnetic Resonance Imaging; Medical and Health Sciences; Neurodegenerative; Neurological; Neurosciences; Primary Progressive; Primary progressive aphasia; Rare Diseases
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URL: https://escholarship.org/uc/item/4td346vg
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Dual mechanisms of cognitive control in bilinguals and monolinguals: A replication ...
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The electrophysiology of voluntary and cued language switching: evidence from event related potentials and neuronal oscillations ...
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Are they really stronger? Comparing effects of semantic variables in speeded deadline and standard picture naming ...
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READING COMPREHENSION CONSTRAINS WORD READING: A TONGUE TWISTER STUDY BY MODERATING ATTENTIONAL CONTROL
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In: Theses and Dissertations--Linguistics (2022)
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The medium is still the message: Canadian federal politicians' gestural stance markers of credibility and opinion
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A psycholinguist who spoke his mouth: Introduction to the special issue on bilingualism in honour of Albert Costa
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In: ISSN: 2327-3798 ; EISSN: 2327-3801 ; Language, Cognition and Neuroscience ; https://hal.archives-ouvertes.fr/hal-03352500 ; Language, Cognition and Neuroscience, Taylor and Francis, 2021, 36 (7), pp.809-813. ⟨10.1080/23273798.2021.1955141⟩ (2021)
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Effect Sizes of Deletions and Duplications on Autism Risk Across the Genome
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In: ISSN: 0002-953X ; EISSN: 1535-7228 ; American Journal of Psychiatry ; https://hal-pasteur.archives-ouvertes.fr/pasteur-03325371 ; American Journal of Psychiatry, American Psychiatric Publishing, 2021, 178 (1), pp.87-98. ⟨10.1176/appi.ajp.2020.19080834⟩ (2021)
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A bio-inspired geometric model for sound reconstruction
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In: ISSN: 2190-8567 ; Journal of Mathematical Neuroscience ; https://hal.archives-ouvertes.fr/hal-02531537 ; Journal of Mathematical Neuroscience, BioMed Central, 2021, 11 (1), pp.2. ⟨10.1186/s13408-020-00099-4⟩ (2021)
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Emerging linguistic universals in communicating neural network agents ; Les universaux linguistiques émergeant dans les réseaux de neurones communicants
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In: https://hal.inria.fr/tel-03536320 ; Cognitive science. Ecole doctorale cerveau-cognition comportement (ED3C), 2021. English (2021)
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An auditory cortex model for sound processing
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In: Geometric Science of Information ; GSI 2021: Geometric Science of Information ; https://hal.archives-ouvertes.fr/hal-03160486 ; GSI 2021: Geometric Science of Information, Jul 2021, Paris, France. ⟨10.1007/978-3-030-80209-7_7⟩ ; https://gsi2021.site.calypso-event.net/ (2021)
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To be or not to be adultlike in syntax: An experimental study of language acquisition and processing in children ...
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Study 2: Can we prevent social identity switches? - A linguistic social identity study ...
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The use of a second language enhances the neural efficiency of inhibitory control: an ERP study ...
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A Replication and Extension of Khodos et al. (2020): To What Extent Does the Age of Onset of Active Bilingualism and Dual Language use Impact Cognitive Control? ...
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The Effects of Bilingualism on Attentional Processes in the First Year of Life ...
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Bilingual code-switch comprehension: Testing the role of cognitive control ...
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Early and Late Implication of Subcortical Brain Structures in Speech Motor Sequence Learning: a Pre-registered fMRI Study ...
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The interplay of morphological-configuration switching and language switching ...
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