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Effects of training with and without cultural adaptations to Latino caregivers of children with autism ...
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Differentiating "Attachment Difficulties" From Autism Spectrum Disorders and Attention Deficit Hyperactivity Disorder: Qualitative Interviews With Experienced Health Care Professionals. ...
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Effects of training with and without cultural adaptations to Latino caregivers of children with autism
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Developmental social communication deficits in the Shank3 rat model of phelan-mcdermid syndrome and autism spectrum disorder.
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Berg, Elizabeth L; Copping, Nycole A; Rivera, Josef K; Pride, Michael C; Careaga, Milo; Bauman, Melissa D; Berman, Robert F; Lein, Pamela J; Harony-Nicolas, Hala; Buxbaum, Joseph D; Ellegood, Jacob; Lerch, Jason P; Wöhr, Markus; Silverman, Jill L
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In: Autism research : official journal of the International Society for Autism Research, vol 11, iss 4 (2018)
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Abstract:
Mutations in the SHANK3 gene have been discovered in autism spectrum disorder (ASD), and the intellectual disability, Phelan-McDermid Syndrome. This study leveraged a new rat model of Shank3 deficiency to assess complex behavioral phenomena, unique to rats, which display a richer social behavior repertoire than mice. Uniquely detectable emissions of ultrasonic vocalizations (USV) in rats serve as situation-dependent affective signals and accomplish important communicative functions. We report, for the first time, a call and response acoustic playback assay of bidirectional social communication in juvenile Shank3 rats. Interestingly, we found that Shank3-deficient null males did not demonstrate the enhanced social approach behavior typically exhibited following playback of pro-social USV. Concomitantly, we discovered that emission of USV in response to playback was not genotype-dependent and emitted response calls were divergent in meaning. This is the first report of these socially relevant responses using a genetic model of ASD. A comprehensive and empirical analysis of vigorous play during juvenile reciprocal social interactions further revealed fewer bouts and reduced durations of time spent playing by multiple key parameters, including reduced anogenital sniffing and allogrooming. We further discovered that male null Shank3-deficient pups emitted fewer isolation-induced USV than Shank3 wildtype controls. Postnatal whole brain anatomical phenotyping was applied to visualize anatomical substrates that underlie developmental phenotypes. The data presented here lend support for the important role of Shank3 in social communication, the core symptom domain of ASD. By increasing the number of in vivo functional outcome measures, we improved the likelihood for identifying and moving forward with medical interventions. Autism Res 2018, 11: 587-601. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.Lay summaryClinically relevant outcomes are required to demonstrate the utility of therapeutics. We introduce findings in a rat model, and assess the impact of mutations in Shank3, an autism risk gene. We found that males with deficient expression of Shank3 did not demonstrate typical responses in a bi-directional social communication test and that social interaction was lower on key parameters. Outcome measures reported herein extend earlier results in mice and capture responses to acoustic calls, which is analogous to measuring receptive and expressive communication.
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Keyword:
2.1 Biological and endogenous factors; Age Factors; Animal; animal model; Animals; autism; Autism Spectrum Disorder; Basic Behavioral and Social Science; behavior; Behavioral and Social Science; Brain Disorders; Chromosome Deletion; Chromosome Disorders; Chromosomes; Clinical Sciences; Communication; Developmental & Child Psychology; Disease Models; DNA Mutational Analysis; Exploratory Behavior; Gene Deletion; Genetic; Human; Intellectual and Developmental Disabilities; Interpersonal Relations; Male; Mental Health; Models; Nerve Tissue Proteins; neurodevelopment; Neurosciences; Pair 22; Pediatric; Phelan McDermid Syndrome; Phenotype; Play and Playthings; Psychology; Rats; shank; social; Social Behavior; synapse; Vocalization
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URL: https://escholarship.org/uc/item/0gn9h5cf
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An interactional ‘live eye tracking’ study in autism spectrum disorder: combining qualitative and quantitative approaches in the study of gaze
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In: Qualitative Research in Psychology (2017) (In press). (2017)
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EFFECTS OF PARTICIPANT CONTROLLED VIDEO PROMPTING ON NOVEL TASKS IN A VOCATIONAL SETTING FOR ADULTS WITH AUTISM SPECTRUM DISORDER
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In: Theses and Dissertations--Early Childhood, Special Education, and Counselor Education (2017)
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Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families.
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In: American journal of human genetics, vol 99, iss 3 (2016)
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Educating students with disabilities in Kenyan primary schools: instructional strategies and teacher preparation ...
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Statistical learning in specific language impairment and Autism Spectrum Disorder: a meta-analysis
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Autism in the classroom: a conversation-analytic study of lesson beginnings in special education
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Phase distortion resulting in a just noticeable difference in the perceived quality of speech
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Analysis of Features for Synthetic Aperture Radar Target Classification
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In: DTIC (2015)
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Comparison of Conversation and Narrative Language Abilities in Children with Autism: Diagnostic and Therapeutic Considerations
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In: Theses and Dissertations (2015)
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| 19 |
ЛИНГВОЦВЕТОВАЯ КАРТИНА МИРА ПРЕДСТАВИТЕЛЕЙ ФРАНЦУЗСКОЙ И РУССКОЙ КУЛЬТУР (НА ПРИМЕРЕ ФРАЗЕОЛОГИИ)
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КУРГУЗЕНКОВА ЖАННА ВЯЧЕСЛАВОВНА. - : Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Российский университет дружбы народов», 2014
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Investigating the cross-cultural validity of DSM-5 autism spectrum disorder: Evidence from Finnish and UK samples.
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In: Autism , 18 (1) 45-54 . (2014) (2014)
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