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Dynamic relationships between phonological memory and reading:a five year longitudinal study from age 4 to 9
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To Name or Not to Name:Eye Movements and Semantic Processing in RAN and Reading
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Auditory frequency discrimination in developmental dyslexia: a meta-analysis
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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On the neural basis of word reading:A meta-analysis of fMRI evidence using activation likelihood estimation
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Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia
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Auditory frequency discrimination in developmental dyslexia: A meta‐analysis
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Further evidence for a parent-of-origin effect at the NOP9 locus on language-related phenotypes
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Genome-wide screening for DNA variants associated with reading and language traits
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Gialluisi, Alessandro; Newbury, Dianne F; Wilcutt, Erik G; Olson, Richard K; DeFries, John C; Brandler, William M; Pennington, Bruce F; Smith, Shelley D; Scerri, Thomas S; Simpson, Nuala H; The SLI Consortium; Luciano, Michelle; Evans, David M; Bates, Timothy C; Stein, John F; Talcott, Joel B; Monaco, Anthony P; Paracchini, Silvia; Francks, Clyde; Fisher, Simon E. - 2015
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Abstract:
This research was funded by: Max Planck Society, the University of St Andrews - Grant Number: 018696, US National Institutes of Health - Grant Number: P50 HD027802, Wellcome Trust - Grant Number: 090532/Z/09/Z, and Medical Research Council Hub Grant Grant Number: G0900747 91070 ; Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome‐wide association scan (GWAS) meta‐analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS was performed in a total of 1862 participants using the first principal component computed from several quantitative measures of reading‐ and language‐related abilities, both before and after adjustment for performance IQ. We identified novel suggestive associations at the SNPs rs59197085 and rs5995177 (uncorrected P ≈ 10–7 for each SNP), located respectively at the CCDC136/FLNC and RBFOX2 genes. Each of these SNPs then showed evidence for effects across multiple reading and language traits in univariate association testing against the individual traits. FLNC encodes a structural protein involved in cytoskeleton remodelling, while RBFOX2 is an important regulator of alternative splicing in neurons. The CCDC136/FLNC locus showed association with a comparable reading/language measure in an independent sample of 6434 participants from the general population, although involving distinct alleles of the associated SNP. Our datasets will form an important part of on‐going international efforts to identify genes contributing to reading and language skills. ; Publisher PDF ; Peer reviewed
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Keyword:
BDC; BF; BF Psychology; CLDRC; Developmental dyslexia; GWAS; Language; Meta-analysis; Pleiotropic variants; QH426; QH426 Genetics; Reading; Reading disability; SLIC; Specific language impairment
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URL: http://hdl.handle.net/10023/6497 https://onlinelibrary.wiley.com/doi/full/10.1111/gbb.12158#support-information-section https://doi.org/10.1111/gbb.12158
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Deconstructing phonological tasks:the contribution of stimulus and response type to the prediction of early decoding skills
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia.
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort
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Genetic analysis of dyslexia candidate genes in the European cross-linguistic NeuroDys cohort.
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In: ISSN: 1018-4813 ; EISSN: 1476-5438 ; European Journal of Human Genetics ; https://hal.archives-ouvertes.fr/hal-00964958 ; European Journal of Human Genetics, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/ejhg.2013.199⟩ (2013)
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