1 |
Individual Differences in Word Recognition (McMurray et al., 2014) ...
|
|
|
|
BASE
|
|
Show details
|
|
2 |
Individual Differences in Word Recognition (McMurray et al., 2014) ...
|
|
|
|
BASE
|
|
Show details
|
|
3 |
Procedural and Declarative Memory Brain Systems in Developmental Language Disorder (DLD)
|
|
|
|
In: Brain Lang (2020)
|
|
BASE
|
|
Show details
|
|
5 |
A Real-time Mechanism Underlying Lexical Deficits in Developmental Language Disorder: Between-Word Inhibition
|
|
|
|
In: Cognition (2019)
|
|
BASE
|
|
Show details
|
|
6 |
Early Literacy Predictors and Second-Grade Outcomes in Children Who Are Hard of Hearing
|
|
|
|
BASE
|
|
Show details
|
|
7 |
Alveolar and Postalveolar Voiceless Fricative and Affricate Productions of Spanish–English Bilingual Children With Cochlear Implants
|
|
|
|
BASE
|
|
Show details
|
|
8 |
Common Genetic Variants In Foxp2 Are Not Associated With Individual Differences In Language Development ...
|
|
|
|
BASE
|
|
Show details
|
|
9 |
An Introduction to the Outcomes of Children with Hearing Loss Study
|
|
|
|
BASE
|
|
Show details
|
|
11 |
Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ
|
|
|
|
BASE
|
|
Show details
|
|
12 |
Longitudinal Speech Perception and Language Performance in Pediatric Cochlear Implant Users: the Effect of Age at Implantation
|
|
|
|
BASE
|
|
Show details
|
|
13 |
Impaired statistical learning of non-adjacent dependencies in adolescents with specific language impairment
|
|
|
|
BASE
|
|
Show details
|
|
15 |
The Influence of Hearing Aids on the Speech and Language Development of Children With Hearing Loss
|
|
|
|
BASE
|
|
Show details
|
|
16 |
Acquisition of Tense Marking in English-Speaking Children with Cochlear Implants: A Longitudinal Study
|
|
|
|
BASE
|
|
Show details
|
|
17 |
Acquisition of Tense Marking in English-Speaking Children with Cochlear Implants: A Longitudinal Study
|
|
|
|
BASE
|
|
Show details
|
|
18 |
Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
|
|
|
|
Abstract:
Language impairment (LI) and reading disability (RD) are common pediatric neurobehavioral disorders that frequently co-occur, suggesting they share etiological determinants. Recently, our group identified prenatal nicotine exposure as a factor for RD and poor reading performance. Using smoking questionnaire and language data from the Avon Longitudinal Study of Parents and Children, we first determined if this risk could be expanded to other communication disorders by evaluating whether prenatal nicotine exposure increases risk for LI and poor performance on language tasks. Prenatal nicotine exposure increased LI risk (OR = 1.60; p = 0.0305) in a dose-response fashion with low (OR = 1.25; p = 0.1202) and high (OR = 3.84; p = 0.0002) exposures. Next, hypothesizing that the effects of prenatal nicotine may also implicate genes that function in nicotine related pathways, we determined whether known nicotine dependence (ND) genes associate with performance on language tasks. We assessed the association of 33 variants previously implicated in ND with LI and language abilities, finding association between ANKK1/DRD2 and performance on language tasks (p≤0.0003). The associations of markers within ANKK1 were replicated in a separate LI case-control cohort (p<0.05). Our results show that smoking during pregnancy increases the risk for LI and poor performance on language tasks and that ANKK1/DRD2 contributes to language performance. More precisely, these findings suggest that prenatal environmental factors influence in utero development of neural circuits vital to language. Our association of ANKK1/DRD2 further implicates the role of nicotine-related pathways and dopamine signaling in language processing, particularly in comprehension and phonological memory. ; Version of Record
|
|
Keyword:
Behavioral Neuroscience; Biology; Clinical Research Design; Complex Traits; Developmental and Pediatric Neurology; Genetic Association Studies; Genetics; Heredity; Human Genetics; Medicine; Neurology; Neuropsychology; Neuroscience; Pediatrics; Survey Research
|
|
URL: https://doi.org/10.1371/journal.pone.0063762 http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181191
|
|
BASE
|
|
Hide details
|
|
19 |
Acquisition of Tense Marking in English-Speaking Children with Cochlear Implants: A Longitudinal Study
|
|
|
|
BASE
|
|
Show details
|
|
20 |
The process of spoken word recognition in the face of signal degradation
|
|
|
|
BASE
|
|
Show details
|
|
|
|