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Damage to Broca’s area does not contribute to long-term speech production outcome after stroke
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In: Brain (2021)
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Right cerebral motor areas that support accurate speech production following damage to cerebellar speech areas
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Geva, Sharon; Schneider, Letitia M.; Roberts, Sophie; Khan, Shamima; Gajardo-Vidal, Andrea; Lorca-Puls, Diego L.; team, PLORAS; Hope, Thomas M.H.; Green, David W.; Price, Cathy J.
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In: Neuroimage Clin (2021)
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Abstract:
Specific regions of the cerebellum are activated when neurologically intact adults speak, and cerebellar damage can impair speech production early after stroke, but how the brain supports accurate speech production years after cerebellar damage remains unknown. We investigated this in patients with cerebellar lesions affecting regions that are normally recruited during speech production. Functional MRI activation in these patients, measured during various single word production tasks, was compared to that of neurologically intact controls, and patient controls with lesions that spared the cerebellar speech production regions. Our analyses revealed that, during a range of speech production tasks, patients with damage to cerebellar speech production regions had greater activation in the right dorsal premotor cortex (r-PMd) and right supplementary motor area (r-SMA) compared to neurologically intact controls. The loci of increased activation in cerebral motor speech areas motivate future studies to delineate the functional contributions of different parts of the speech production network, and test whether non-invasive stimulation to r-PMd and r-SMA facilitates speech recovery after cerebellar stroke.
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Keyword:
Regular Article
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URL: https://doi.org/10.1016/j.nicl.2021.102820
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517928/
http://www.ncbi.nlm.nih.gov/pubmed/34653836
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