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Subtle mistakes in self‐report surveys predict future transition to dementia
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Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF
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In: BioMed Central (2020)
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Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF
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In: BMC Molecular and Cell Biology ; 21 (2020). - 64. - BioMed Central. - eISSN 2661-8850 (2020)
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Abstract:
Background It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the cascade of VWF-platelet interactions in haemostasis. Results Combining microfluidic tools with fluorescence and reflection interference contrast microscopy (RICM), here we show, that specific deletions in the A-domains of the biopolymer VWF affect both, adhesion and aggregation properties independently. Intuitively, the deletion of the A1-domain led to a significant decrease in both adhesion and aggregate formation of platelets. Nevertheless, the deletion of the A2-domain revealed a completely different picture, with a significant increase in formation of rolling aggregates (gain of function). We predict that the A2-domain effectively ‘masks’ the potential between the platelet glycoprotein (GP) Ib and the VWF A1-domain. Furthermore, the deletion of the A3-domain led to no significant variation in either of the two functional characteristics. Conclusions These data demonstrate that the macroscopic functional properties i.e. adhesion and aggregate formation cannot simply be assigned to the properties of one particular domain, but have to be explained by cooperative phenomena. The absence or presence of molecular entities likewise affects the properties (thermodynamic phenomenology) of its neighbours, therefore altering the macromolecular function. ; published
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Keyword:
ddc:540
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URL: https://doi.org/10.1186/s12860-020-00309-7 http://nbn-resolving.de/urn:nbn:de:bsz:352-2-1934thdvqba9n7
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Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF
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In: BMC Mol Cell Biol (2020)
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Constructions parenthétiques, marques d’oralité et type de textes en diachronie du français
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In: Nouvelles voies d’accès au changement linguistique ; https://halshs.archives-ouvertes.fr/halshs-03549250 ; Ayres-Bennett (Wendy), Carlier (Anne), Glikman (Julie), Rainsford (Thomas M.), Siouffi (Gilles), Skupien Dekens (Carine). Nouvelles voies d’accès au changement linguistique, Classiques Garnier, pp.317 - 334, 2018, Histoire et évolution du français, 978-2-406-06946-1. ⟨10.15122/isbn.978-2-406-06946-1.p.0317⟩ (2018)
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Linguistic Indicators of Pain Catastrophizing in Patients with Chronic Musculoskeletal Pain
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Parenthetical verbs : [... presented at the workshop Parenthetical Verbs: Hypotaxis, Parataxis or Parenthesis?, held 24 - 26 May 2012 at the Paris West University Nanterre La Défense]
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BLLDB
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UB Frankfurt Linguistik
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