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Certification, enseignement supérieur, recherche et innovation : mon CLES en 180 secondes
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In: XXVIIIe Congrès RANACLES - (Dis)continuité des apprentissages en langues ; https://hal.univ-lille.fr/hal-03536510 ; XXVIIIe Congrès RANACLES - (Dis)continuité des apprentissages en langues, Annick Rivens Mompean, Centre de langues de l'université de Lille (CLIL), Nov 2021, Villeneuve d'Ascq, France ; https://ranacles2021.sciencesconf.org/ (2021)
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Quantifying Sources of Variability in Infancy Research Using the Infant-Directed-Speech Preference
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In: ISSN: 2515-2459 ; EISSN: 2515-2467 ; Advances in Methods and Practices in Psychological Science ; https://hal-univ-rennes1.archives-ouvertes.fr/hal-02509817 ; Advances in Methods and Practices in Psychological Science, [Thousand Oaks]: [SAGE Publications], 2020, 3 (1), pp.24-52. ⟨10.1177/2515245919900809⟩ (2020)
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PCC effects with se-reflexives in causative constructions
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In: Papers of the Linguistics Society of Belgium (Vol. 14) ; https://hal.archives-ouvertes.fr/hal-03263790 ; Papers of the Linguistics Society of Belgium (Vol. 14), 2020 (2020)
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3rd Person Needs Licensing Too: Examining the se/suu Connection
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In: Studies in Polish Linguistics (ISSN 1732-8160) ; https://hal.archives-ouvertes.fr/hal-03263705 ; Studies in Polish Linguistics (ISSN 1732-8160), 2019, pp.11-33. ⟨10.4467/23005920SPL.19.004.10984⟩ ; https://www.ejournals.eu/SPL/Special-Volume/Special-Volume-1/art/15097/ (2019)
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Clausal pied-piping in Basque wh-questions and syntactic optionality
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In: ConSOLE XXV: Proceedings of the 25th Conference of the Student Organisation of Linguistics in Europe (4-6 January 2017, Leipzig) ; https://hal.archives-ouvertes.fr/hal-03263793 ; ConSOLE XXV: Proceedings of the 25th Conference of the Student Organisation of Linguistics in Europe (4-6 January 2017, Leipzig), 2018 (2018)
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Romance reflexives, past participle agreement and the PCC
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In: Proceedings of NELS 48 ; https://hal.archives-ouvertes.fr/hal-03263794 ; Proceedings of NELS 48, 2018 (2018)
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Reflexives and participants: a natural class
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In: ConSOLE XXVI: Proceedings of the 26th Conference of the Student Organisation of Linguistics in Europe (14-16 January 2018, University College London) ; https://hal.archives-ouvertes.fr/hal-03263791 ; ConSOLE XXVI: Proceedings of the 26th Conference of the Student Organisation of Linguistics in Europe (14-16 January 2018, University College London), 2018 (2018)
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Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal.archives-ouvertes.fr/hal-01382787 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2017, 11 (5), pp.1497-1514. ⟨10.1007/s11682-016-9629-z⟩ (2017)
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Novel genetic loci underlying human intracranial volume identified through genome-wide association
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In: ISSN: 1097-6256 ; EISSN: 1546-1726 ; Nature Neuroscience ; https://hal.archives-ouvertes.fr/hal-01382716 ; Nature Neuroscience, Nature Publishing Group, 2016, 19 (12), pp.1569-1582. ⟨10.1038/nn.4398⟩ (2016)
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ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
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In: ISSN: 1053-8119 ; EISSN: 1095-9572 ; NeuroImage ; https://hal.archives-ouvertes.fr/hal-01380998 ; NeuroImage, Elsevier, 2015, ⟨10.1016/j.neuroimage.2015.11.057⟩ (2015)
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The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
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In: ISSN: 1931-7557 ; EISSN: 1931-7565 ; Brain imaging and behavior (Brain Imaging Behav) ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01967166 ; Brain imaging and behavior (Brain Imaging Behav), Secaucus, NJ : Springer, 2014, 8 (2), pp.152-182. ⟨10.1007/s11682-013-9269-5⟩ (2014)
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Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism
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El-Kordi, Ahmed; Winkler, Daniela; Hammerschmidt, Kurt; Kästner, Anne; Krueger, Dilja; Ronnenberg, Anja; Ritter, Caroline; Jatho, Jasmin; Radyushkin, Konstantin; Bourgeron, Thomas; Fischer, Julia; Brose, Nils; Ehrenreich, Hannelore
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In: ISSN: 0166-4328 ; EISSN: 1872-7549 ; Behavioural Brain Research ; https://hal-pasteur.archives-ouvertes.fr/pasteur-01580131 ; Behavioural Brain Research, Elsevier, 2013, 251 (1), pp.41 - 49. ⟨10.1016/j.bbr.2012.11.016⟩ (2013)
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Abstract:
International audience ; Autism is the short name of a complex and heterogeneous group of disorders (autism spectrum disorders, ASD) with several lead symptoms required for classification, including compromised social interaction, reduced verbal communication and stereotyped repetitive behaviors/restricted interests. The etiology of ASD is still unknown in most cases but monogenic heritable forms exist that have provided insights into ASD pathogenesis and have led to the notion of autism as a 'synapse disorder'. Among the most frequent monogenic causes of autism are loss-of-function mutations of the NLGN4X gene which encodes the synaptic cell adhesion protein neuroligin-4X (NLGN4X). We previously described autism-like behaviors in male Nlgn4 null mutant mice, including reduced social interaction and ultrasonic communication. Here, we extend the phenotypical characterization of Nlgn4 null mutant mice to both genders and add a series of additional autism-relevant behavioral readouts. We now report similar social interaction and ultrasonic communication deficits in females as in males. Furthermore, aggression, nest-building parameters, as well as self-grooming and circling as indicators of repetitive behaviors/stereotypies were explored in both genders. The construction of a gender-specific autism severity composite score for Nlgn4 mutant mice markedly diminishes population/sample heterogeneity typically obtained for single tests, resulting in p values of <0.00001 and a genotype predictability of 100% for male and of >83% for female mice. Taken together, these data underscore the similarity of phenotypical consequences of Nlgn4/NLGN4X loss-of-function in mouse and man, and emphasize the high relevance of Nlgn4 null mutant mice as an ASD model with both construct and face validity.
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Keyword:
[SCCO]Cognitive science; [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health; [SDV]Life Sciences [q-bio]; Animal; ASD; Gender differences; Grooming; Knockout; MESH: Animals; MESH: Autistic Disorder; MESH: Behavior; MESH: Carrier Proteins; MESH: Cell Adhesion Molecules; MESH: Disease Models; MESH: Female; MESH: Genetic Predisposition to Disease; MESH: Grooming; MESH: Male; MESH: Membrane Proteins; MESH: Mice; MESH: Phenotype; MESH: Severity of Illness Index; MESH: Sex Characteristics; MESH: Social Behavior; MESH: Stereotyped Behavior; MESH: Vocalization; Nest building; Neuronal; Repetitive behaviors; Social interaction; Stereotypies; Ultra-sound vocalization
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URL: https://doi.org/10.1016/j.bbr.2012.11.016
https://hal-pasteur.archives-ouvertes.fr/pasteur-01580131
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| 14 |
This article will appear in:
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In: http://www.cultnet.english.arts.tu.ac.th/members/susanne_weber/susanne weber_juni _3_.pdf
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