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A core outcome set for aphasia treatment research: The ROMA consensus statement
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In: Research outputs 2014 to 2021 (2019)
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When does lexical availability influence phonology? Evidence from Jargon reading and repetition ...
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When does lexical availability influence phonology? Evidence from Jargon reading and repetition ...
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What can repetition, reading and naming tell us about Jargon Aphasia?
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Speech and language therapists’ perspectives of therapeutic alliance construction and maintenance in aphasia rehabilitation post‐stroke
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A core outcome set for aphasia treatment research: the ROMA consensus statement
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A core outcome set for aphasia treatment research: the ROMA consensus statement
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Sources of Phoneme Errors in Repetition: Perseverative, Neologistic, and Lesion Patterns in Jargon Aphasia
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Sources of phoneme errors in repetition: perseverative, neologistic and lesion patterns in jargon aphasia
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ImPACT: a multifaceted implementation for conversation partner training in aphasia in Dutch rehabilitation settings ...
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ImPACT: a multifaceted implementation for conversation partner training in aphasia in Dutch rehabilitation settings ...
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Mismatch negativity (MMN) reveals inefficient auditory ventral stream function in chronic auditory comprehension impairments
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Abstract:
BACKGROUND: Auditory discrimination is significantly impaired in Wernicke's aphasia (WA) and thought to be causatively related to the language comprehension impairment which characterises the condition. This study used mismatch negativity (MMN) to investigate the neural responses corresponding to successful and impaired auditory discrimination in WA. METHODS: Behavioural auditory discrimination thresholds of consonant-vowel-consonant (CVC) syllables and pure tones (PTs) were measured in WA (n = 7) and control (n = 7) participants. Threshold results were used to develop multiple deviant MMN oddball paradigms containing deviants which were either perceptibly or non-perceptibly different from the standard stimuli. MMN analysis investigated differences associated with group, condition and perceptibility as well as the relationship between MMN responses and comprehension (within which behavioural auditory discrimination profiles were examined). RESULTS: MMN waveforms were observable to both perceptible and non-perceptible auditory changes. Perceptibility was only distinguished by MMN amplitude in the PT condition. The WA group could be distinguished from controls by an increase in MMN response latency to CVC stimuli change. Correlation analyses displayed a relationship between behavioural CVC discrimination and MMN amplitude in the control group, where greater amplitude corresponded to better discrimination. The WA group displayed the inverse effect; both discrimination accuracy and auditory comprehension scores were reduced with increased MMN amplitude. In the WA group, a further correlation was observed between the lateralisation of MMN response and CVC discrimination accuracy; the greater the bilateral involvement the better the discrimination accuracy. CONCLUSIONS: The results from this study provide further evidence for the nature of auditory comprehension impairment in WA and indicate that the auditory discrimination deficit is grounded in a reduced ability to engage in efficient hierarchical processing and the construction of invariant auditory objects. Correlation results suggest that people with chronic WA may rely on an inefficient, noisy right hemisphere auditory stream when attempting to process speech stimuli.
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Keyword:
R Medicine (General); RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
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URL: http://orca.cf.ac.uk/74865/1/1-s2.0-S0010945214002305-main.pdf http://orca.cf.ac.uk/74865/ https://doi.org/10.1016/j.cortex.2014.07.009
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The anterior temporal lobes support residual comprehension in Wernicke’s aphasia
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Facilitating and disrupting speech perception in word deafness
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Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke’s aphasia
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