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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia. ...
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Sala, Arianna; Malpetti, Maura; Farsad, Mohsen; Lubian, Francesca; Magnani, Giuseppe; Frasca Polara, Giulia; Epiney, Jean-Benoit; Abutalebi, Jubin; Assal, Frédéric; Garibotto, Valentina; Perani, Daniela. - : Apollo - University of Cambridge Repository, 2022
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Abstract:
Lifelong bilingualism is associated with delayed dementia onset, suggesting a protective effect on the brain. Here, we aim to study the effects of lifelong bilingualism as a dichotomous and continuous phenomenon, on brain metabolism and connectivity in individuals with Alzheimer's dementia. Ninety-eight patients with Alzheimer's dementia (56 monolinguals; 42 bilinguals) from three centers entered the study. All underwent an [18F]-fluorodeoxyglucose positron emission tomography (PET) imaging session. A language background questionnaire measured the level of language use for conversation and reading. Severity of brain hypometabolism and strength of connectivity of the major neurocognitive networks was compared across monolingual and bilingual individuals, and tested against the frequency of second language life-long usage. Age, years of education, and MMSE score were included in all above mentioned analyses as nuisance covariates. Cerebral hypometabolism was more severe in bilingual compared to monolingual ...
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Keyword:
Alzheimer disease; default mode network; fluorodeoxyglucose F18; multilingualism; positron‐emission tomography; RESEARCH ARTICLE; RESEARCH ARTICLES
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URL: https://dx.doi.org/10.17863/cam.77664
https://www.repository.cam.ac.uk/handle/1810/330222
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Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.
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