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Syntactic and Semantic Specialization and Integration in 5- to 6-Year-Old Children during Auditory Sentence Processing
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Family-based genetic investigation of SLI (Andres et al., 2020) ...
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Family-based genetic investigation of SLI (Andres et al., 2020) ...
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Abstract:
Purpose: Specific language impairment (SLI) is characterized by a delay in language acquisition despite a lack of other developmental delays or hearing loss. Genetics of SLI is poorly understood. The purpose of this study is to identify SLI genetic loci through family-based linkage mapping. Method: We performed genome-wide parametric linkage analysis in six families segregating with SLI. An age-appropriate standardized omnibus language measure was used to categorically define the SLI phenotype. Results: A suggestive linkage region replicated a previous region of interest with the highest logarithm of odds (LOD) score of 2.40 at 14q11.2-q13.3 in Family 489. A paternal parent-of-origin effect associated with SLI and language phenotypes on a nonsynonymous single nucleotide polymorphism (SNP) in NOP9 (14q12) was reported previously. Linkage analysis identified a new SLI locus at 15q24.3-25.3 with the highest parametric LOD score of 3.06 in Family 315 under a recessive mode of inheritance. Suggestive evidence of ...
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Keyword:
Language
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URL: https://dx.doi.org/10.23641/asha.13203218 https://asha.figshare.com/articles/journal_contribution/Family-based_genetic_investigation_of_SLI_Andres_et_al_2020_/13203218
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, Panel Discussion on Specific Language Impairment ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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2019 ASHA Research Symposium: Mabel L. Rice, What Studies of Twins Tell Us About Specific Language Impairment in Children: Twinning Effects & Heritability at 2, 4, 6, and 16 Years of Age ...
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Causal Pathways for Specific Language Impairment: Lessons From Studies of Twins
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In: J Speech Lang Hear Res (2020)
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Pedigree-Based Gene Mapping Supports Previous Loci and Reveals Novel Suggestive Loci in Specific Language Impairment
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In: J Speech Lang Hear Res (2020)
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Advances in Specific Language Impairment Research and Intervention: An Overview of Five Research Symposium Papers
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In: J Speech Lang Hear Res (2020)
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Heritability of Specific Language Impairment and Nonspecific Language Impairment at Ages 4 and 6 Years Across Phenotypes of Speech, Language, and Nonverbal Cognition
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In: J Speech Lang Hear Res (2020)
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Birth Prevalence of Congenital Cytomegalovirus Infection in HIV-Exposed Uninfected Children in the Era of Combination Antiretroviral Therapy
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In: J Pediatr (2019)
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Prenatal and perinatal risks for late language emergence in a population-level sample of twins at age 2
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Grammar Clinical Marker Yields Substantial Heritability for Language Impairments in 16-Year-Old Twins
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Risk for Speech and Language Impairments in Pre-school Aged HIV-Exposed Uninfected Children with in utero Combination Antiretroviral Exposure
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Mapping Chromosomal Loci in Specific Language Impairment: A Pedigree-Focused Approach
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Effects of Language Context on Ratings of Shy and Unsociable Behaviors in English Language Learning Children
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