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Not All Procedural Learning Tasks Are Difficult for Adults With Developmental Language Disorder
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In: J Speech Lang Hear Res (2021)
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Auditory bombardment and treatment (Plante et al., 2018) ...
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Auditory bombardment and treatment (Plante et al., 2018) ...
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Learning Without Trying: The Clinical Relevance of Statistical Learning
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Exemplar variability and word learning by children with SLI (Aguilar et al., 2017) ...
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Exemplar variability and word learning by children with SLI (Aguilar et al., 2017) ...
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Exemplar variability and word learning by children with SLI (Aguilar et al., 2017) ...
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Neural Correlates of Morphology Acquisition through a Statistical Learning Paradigm
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Evidence that neurovascular coupling underlying the BOLD effect increases with age during childhood
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Schmithorst, Vincent J.; Vannest, Jennifer; Lee, Gregory; Hernandez‐garcia, Luis; Plante, Elena; Rajagopal, Akila; Holland, Scott K.. - : Saunders, 2015. : Wiley Periodicals, Inc., 2015
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Abstract:
Functional MRI using blood–oxygen‐level‐dependent (BOLD) imaging has provided unprecedented insights into the maturation of the human brain. Task‐based fMRI studies have shown BOLD signal increases with age during development (ages 5–18) for many cognitive domains such as language and executive function, while functional connectivity (resting‐state) fMRI studies investigating regionally synchronous BOLD fluctuations have revealed a developing functional organization of the brain from a local into a more distributed architecture. However, interpretation of these results is confounded by the fact that the BOLD signal is directly related to blood oxygenation driven by changes in blood flow and only indirectly related to neuronal activity, and may thus be affected by changing neuronal–vascular coupling. BOLD signal and cerebral blood flow (CBF) were measured simultaneously in a cohort of 113 typically developing awake participants ages 3–18 performing a narrative comprehension task. Using a novel voxelwise wild bootstrap analysis technique, an increased ratio of BOLD signal to relative CBF signal change with age (indicative of increased neuronal–vascular coupling) was seen in the middle temporal gyri and the left inferior frontal gyrus. Additionally, evidence of decreased relative oxygen metabolism (indicative of decreased neuronal activity) with age was found in the same regions. These findings raise concern that results of developmental BOLD studies cannot be unambiguously attributed to neuronal activity. Astrocytes and astrocytic processes may significantly affect the maturing functional architecture of the brain, consistent with recent research demonstrating a key role for astrocytes in mediating increased CBF following neuronal activity and for astrocyte processes in modulating synaptic connectivity. Hum Brain Mapp, 36:1–15, 2015 . © 2014 Wiley Periodicals, Inc . ; Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/110113/1/hbm22608.pdf
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Keyword:
Children; Developmental Studies; Functional MRI; Health Sciences; Kinesiology and Sports; Language Processing; Neuronal–Vascular Coupling; Neurosciences
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URL: https://doi.org/10.1002/hbm.22608 https://hdl.handle.net/2027.42/110113
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The nature of the language input affects brain activation during learning from a natural language
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Executive Function in SLI: Recent Advances and Future Directions
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Dynamic Changes in Network Activations Characterize Early Learning of a Natural Language
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A stereoscopic system for viewing the temporal evolution of brain activity clusters in response to linguistic stimuli ...
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A stereoscopic system for viewing the temporal evolution of brain activity clusters in response to linguistic stimuli
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A 10-year longitudinal fMRI study of narrative comprehension in children and adolescents
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Modulating the Focus of Attention for Spoken Words at Encoding Affects Frontoparietal Activation for Incidental Verbal Memory
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