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Age of acquisition effects on traditional Chinese character naming and lexical decision. ...
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Age of acquisition effects on traditional Chinese character naming and lexical decision.
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Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood. ...
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Using Polygenic Profiles to Predict Variation in Language and Psychosocial Outcomes in Early and Middle Childhood.
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Abstract:
Purpose Children with poor language tend to have worse psychosocial outcomes compared to their typically developing peers. The most common explanations for such adversities focus on developmental psychological processes whereby poor language triggers psychosocial difficulties. Here, we investigate the possibility of shared biological effects by considering whether the same genetic variants, which are thought to influence language development, are also predictors of elevated psychosocial difficulties during childhood. Method Using data from the U.K.-based Avon Longitudinal Study of Parents and Children, we created a number of multi-single-nucleotide polymorphism polygenic profile scores, based on language and reading candidate genes (ATP2C2, CMIP, CNTNAP2, DCDC2, FOXP2, and KIAA0319, 1,229 single-nucleotide polymorphisms) in a sample of 5,435 children. Results A polygenic profile score for expressive language (8 years) that was created in a discovery sample (n = 2,718) predicted not only expressive language (8 years) but also peer problems (11 years) in a replication sample (n = 2,717). Conclusions These findings provide a proof of concept for the use of such a polygenic approach in child language research when larger data sets become available. Our indicative findings suggest consideration should be given to concurrent intervention targeting both linguistic and psychosocial development as early language interventions may not stave off later psychosocial difficulties in children.
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Keyword:
Age Factors; Child; Child Language; Cohort Studies; Female; Humans; Infant; Language; Male; Multifactorial Inheritance; Preschool; Psychology
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URL: https://doi.org/10.17863/CAM.39549 https://www.repository.cam.ac.uk/handle/1810/292399
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Action mechanisms for social cognition: behavioral and neural correlates of developing Theory of Mind.
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In: Developmental science, vol 20, iss 5 (2017)
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Prevalence of face recognition deficits in middle childhood.
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Electrophysiological evidence of heterogeneity in visual statistical learning in young children with ASD.
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In: Developmental science, vol 18, iss 1 (2015)
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Predictors of longitudinal outcome and recovery of pragmatic language and its relation to externalizing behaviour after pediatric traumatic brain injury
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Cognitive development in females with PCDH19 gene-related epilepsy
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Follow the liar: the effects of adult lies on children's honesty.
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In: Developmental science, vol 17, iss 6 (2014)
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Bilateral versus unilateral cochlear implants in children: a study of spoken language outcomes
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Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2014)
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The relationship between ventricular size at 1 month and outcome at 2 years in infants less than 30 weeks' gestation
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The perception of prosody and associated auditory cues in early-implanted children: the role of auditory working memory and musical activities.
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In: Int J Audiol , 53 (3) 182 - 191. (2014) (2014)
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Three-year-olds hide their communicative intentions in appropriate contexts.
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What's in a link: associative and taxonomic priming effects in the infant lexicon.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; CrossRef (2013)
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Predicate structures, gesture, and simultaneity in the representation of action in British Sign Language: evidence from deaf children and adults.
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In: J Deaf Stud Deaf Educ , 18 (3) 370 - 390. (2013) (2013)
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Effect of teenage motherhood on cognitive outcomes in children: a population-based cohort study.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2013)
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TM4SF20 ancestral deletion and susceptibility to a pediatric disorder of early language delay and cerebral white matter hyperintensities.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2013)
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Generalist genes and cognitive abilities in Chinese twins.
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In: Symplectic Elements at Oxford ; Europe PubMed Central ; PubMed (http://www.ncbi.nlm.nih.gov/pubmed/) ; Web of Science (Lite) (http://apps.webofknowledge.com/summary.do) ; Scopus (http://www.scopus.com/home.url) ; CrossRef (2013)
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