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All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year AND OR AND NOT All fields Title Creator / Publisher Keyword Year Sort by creator [A → Z]' creator [Z → A]' publishing year ↑ (asc)' publishing year ↓ (desc)' title [A → Z]' title [Z → A]' Simple Search Page: 1 2 Hits 1 – 20 of 26 1 Planum Temporale Morphology in Children with Developmental Dyslexia Bloom, Juliana Sanchez; Garcia-Barrera, Mauricio A.; Miller, Carlin J.. - 2013 BASE Show details 2 The Aromatase Gene CYP19A1: Several Genetic and Functional Lines of Evidence Supporting a Role in Reading, Speech and Language Anthoni, Heidi; Sucheston, Lara E.; Lewis, Barbara A.; Tapia-Páez, Isabel; Fan, Xiaotang; Zucchelli, Marco; Taipale, Mikko; Stein, Catherine M.; Hokkanen, Marie-Estelle; Castrén, Eero; Pennington, Bruce F.; Smith, Shelley D.; Olson, Richard K.; Tomblin, J. Bruce; Schulte-Körne, Gerd; Nöthen, Markus; Schumacher, Johannes; Müller-Myhsok, Bertram; Hoffmann, Per; Gilger, Jeffrey W.; Hynd, George W.; Nopola-Hemmi, Jaana; Leppanen, Paavo H. T.; Lyytinen, Heikki; Schoumans, Jacqueline; Nordenskjöld, Magnus; Spencer, Jason; Stanic, Davor; Boon, Wah Chin; Simpson, Evan; Mäkelä, Sari; Gustafsson, Jan-Åke; Peyrard-Janvid, Myriam; Iyengar, Sudha; Kere, Juha. - : Springer US, 2012 Abstract: Inspired by the localization, on 15q21.2 of the CYP19A1 gene in the linkage region of speech and language disorders, and a rare translocation in a dyslexic individual that was brought to our attention, we conducted a series of studies on the properties of CYP19A1 as a candidate gene for dyslexia and related conditions. The aromatase enzyme is a member of the cytochrome P450 super family, and it serves several key functions: it catalyzes the conversion of androgens into estrogens; during early mammalian development it controls the differentiation of specific brain areas (e.g. local estrogen synthesis in the hippocampus regulates synaptic plasticity and axonal growth); it is involved in sexual differentiation of the brain; and in songbirds and teleost fishes, it regulates vocalization. Our results suggest that variations in CYP19A1 are associated with dyslexia as a categorical trait and with quantitative measures of language and speech, such as reading, vocabulary, phonological processing and oral motor skills. Variations near the vicinity of its brain promoter region altered transcription factor binding, suggesting a regulatory role in CYP19A1 expression. CYP19A1 expression in human brain correlated with the expression of dyslexia susceptibility genes such as DYX1C1 and ROBO1. Aromatase-deficient mice displayed increased cortical neuronal density and occasional cortical heterotopias, also observed in Robo1−/− mice and human dyslexic brains, respectively. An aromatase inhibitor reduced dendritic growth in cultured rat neurons. From this broad set of evidence, we propose CYP19A1 as a candidate gene for human cognitive functions implicated in reading, speech and language. Keyword: Original Research URL: https://doi.org/10.1007/s10519-012-9532-3 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375077 http://www.ncbi.nlm.nih.gov/pubmed/22426781 BASE Hide details 3 Reading fluency: implications for the assessment of children with reading disabilities Hynd, George W.; Bloom, Juliana S.; Meisinger, Elizabeth B. In: Annals of dyslexia. - New York, NY : Springer 60 (2010) 1, 1-17 BLLDB OLC Linguistik Show details 4 The pars triangularis in dyslexia and ADHD: A comprehensive approach Kibby, Michelle Y.; Kroese, Judith M.; Krebbs, Hillery... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 111 (2009) 1, 46-54 OLC Linguistik Show details 5 The pars triangularis in dyslexia and ADHD: a comprehensive approach Kibby, Michelle Y.; Krebbs, Hillery; Kroese, Judith M.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 111 (2009) 1, 46-54 BLLDB OLC Linguistik Show details 6 The relationship between cerebral hemisphere volume and receptive language functioning in dyslexia and attention-deficit hyperactivity disorder (ADHD). Kibby, Michelle Y; Pavawalla, Shital P; Fancher, Jill B.... In: Publications (2009) BASE Show details 7 The Pars Triangularis in Dyslexia and ADHD: A Comprehensive Approach Kibby, Michelle Y.; Kroese, Judith M.; Krebbs, Hillery. - 2009 BASE Show details 8 A Quantitative Magnetic Resonance Imaging Analysis of the Cerebellar Deficit Hypothesis of Dyslexia Kibby, Michelle Y; Fancher, Jill B.; Markanen, Rochelle... In: Publications (2008) BASE Show details 9 Testing the double-deficit hypothesis in an adult sample Miller, Carlin J.; Miller, Scott R.; Bloom, Juliana S.... In: Annals of dyslexia. - Boston, Mass. : Springer 56 (2006) 1, 83-102 BLLDB Show details 10 Children with dyslexia: not necessarily at risk for elevated internalizing symptoms Miller, Scott R.; Miller, Carlin J.; Hynd, George W. In: Reading and writing. - New York, NY : Springer Science+Business Media 18 (2005) 5, 425-436 BLLDB OLC Linguistik Show details 11 The relationship between perisylvian morphology and verbal short-term memory functioning in children with neurodevelopmental disorders Kibby, Michelle Y.; Kroese, Judith M.; Morgan, Allison E.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 89 (2004) 1, 122-135 OLC Linguistik Show details 12 The relationship between perisylvian morphology and verbal short-term memory functioning in children with neurodevelopmental disorders Kibby, Michelle Y.; Kroese, Judith M.; Morgan, Allison E.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 89 (2004) 1, 122-135 BLLDB Show details 13 Sulcal-Gyral Pattern Morphology of the Perisylvian Language Region in Developmental Dyslexia Hiemenz, Jennifer R.; Hynd, George W. In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 74 (2000) 1, 113-133 OLC Linguistik Show details 14 Rapid Naming Deficits in Children and Adolescents with Reading Disabilities and Attention Deficit Hyperactivity Disorder Semrud-Clikeman, Margaret; Guy, Kathryn; Griffin, Julie D.... In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 74 (2000) 1, 70-83 OLC Linguistik Show details 15 Sulcal/gyral pattern morphology of the perisylvian language region in developmental Dyslexia Hiemenz, Jennifer R.; Hynd, George W. In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 74 (2000) 1, 113-133 BLLDB Show details 16 Clinical appraisal of spelling ability and its relationship to phonemic awareness (blending, segmenting, elision, and reversal), phonological memory, and reading in reading disabled, ADHD, and normal children Kroese, Judith M.; Hynd, George W.; Knight, Deborah F.... In: Reading and writing. - New York, NY : Springer Science+Business Media 13 (2000) 1, 105-132 OLC Linguistik Show details 17 Clinical appraisal of spelling ability and its relationship to phonemic awareness (blending, segmenting, elision, and reversal), phonological memory, and reading in reading disabled, ADHD, and normal children Kroese, Judith M.; Hynd, George W.; Knight, Deborah F.... In: Reading and writing. - Dordrecht [u.a.] : Springer Science + Business Media B.V 13 (2000) 1-2, 105-131 BLLDB Show details 18 Dyslexia : a developmental language-based learning difference Richardson, Sylvia O. (Hrsg.); Riccio, Cynthia A. (Mitarb.); Hynd, George W. (Mitarb.)... In: Topics in language disorders. - Hagerstown, Md. : Lippincott Williams & Wilkins 16 (1996) 2, 1-86 BLLDB Show details 19 Learning disabilities : neuroanatomic asymmetries Hynd, George W.; Marshall, Richard; Hall, Josh... In: Brain asymmetry (Cambridge, Mass., 1994), p. 617-636 MPI für Psycholinguistik Show details 20 Receptive prosody in children with left or right hemisphere dysfunction Cohen, Morris J.; Branch, Walter B.; Hynd, George W. In: Brain & language. - Orlando, Fla. [u.a.] : Elsevier 47 (1994) 2, 171-181 BLLDB Show details Page: 1 2

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